We are analyzing https://link.springer.com/article/10.1007/s40139-017-0139-5.

Title:
Autophagy and Ferroptosis—What Is the Connection? | Current Pathobiology Reports
Description:
Purpose of Review Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.
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Topics {✒️}

oncogenic-ras-harboring cancer cells p62-keap1-nrf2 pathway protects month download article/chapter iron-dependent cell death acyl-coa synthetase-4 research scholar grant daolin tang declare mitochondrial lipid peroxidation bravo-san pedro jm p53-mediated ferroptotic responses genotype-selective antitumor agents cell signal 28 full article pdf iron-dependent form daolin tang lipid peroxidation molecular life sciences adaptive stress responses privacy choices/manage cookies dixon sj autophagy-related proteins author information authors integrated strategy reveals bone marrow injury animal subjects performed related subjects ros-induced autophagy p53-mediated activity autophagic cell death negative breast cancer check access instant access autophagy promotes ferroptosis pancreatic cancer cells cancer cells assists hepatocellular carcinoma cells cell death subroutines nonapoptotic cell death immunogenic cell death pathobiology rights cancer targets bcl-2 american cancer society regulated cell death p53-mediated ferroptosis article kang angeli jp article log yang ws european economic area maintaining mitochondrial homeostasis

Questions {❓}

Autophagy and Ferroptosis—What Is the Connection?
Autophagy and Ferroptosis—What Is the Connection?
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ (2014) Drugging the undruggable RAS: mission possible?
Green DR, Levine B (2014) To be or not to be?

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