We are analyzing https://link.springer.com/article/10.1007/s12033-024-01222-6.

Title:
Clearing the Path: Exploring Apoptotic Cell Clearance in Inflammatory and Autoimmune Disorders for Therapeutic Advancements | Molecular Biotechnology
Description:
Abstract Inflammatory and autoimmune disorders, characterized by dysregulated immune responses leading to tissue damage and chronic inflammation, present significant health challenges. This review uniquely focuses on efferocytosis—the phagocyte-mediated clearance of apoptotic cells—and its pivotal role in these disorders. We delve into the intricate mechanisms of efferocytosis’ four stages and their implications in disease pathogenesis, distinguishing our study from previous literature. Our findings highlight impaired efferocytosis in conditions like atherosclerosis and asthma, proposing its targeting as a novel therapeutic strategy. We discuss the therapeutic potential of efferocytosis in modulating immune responses and resolving inflammation, offering a new perspective in treating inflammatory disorders. Graphical Abstract
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

What’s the deal with efferocytosis and asthma?

Schema {🗺️}

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         description:Inflammatory and autoimmune disorders, characterized by dysregulated immune responses leading to tissue damage and chronic inflammation, present significant health challenges. This review uniquely focuses on efferocytosis—the phagocyte-mediated clearance of apoptotic cells—and its pivotal role in these disorders. We delve into the intricate mechanisms of efferocytosis’ four stages and their implications in disease pathogenesis, distinguishing our study from previous literature. Our findings highlight impaired efferocytosis in conditions like atherosclerosis and asthma, proposing its targeting as a novel therapeutic strategy. We discuss the therapeutic potential of efferocytosis in modulating immune responses and resolving inflammation, offering a new perspective in treating inflammatory disorders.
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      name:Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, Novara, Italy
      name:Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
      name:Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
      name:Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
      name:Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
      name:Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
      name:Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
      name:Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
      name:Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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