
NCBI . NLM . NIH . GOV {
}
Title[redir]:
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice - PMC
Description:
Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of ...
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Keywords {🔍}
nps, fig, sirna, mice, macrophages, cells, free, doi, scholar, pubmed, google, spsicamkg, pmc, camkiiγ, plaque, article, cell, atherosclerotic, pbs, ldlr, targeted, hours, lesional, blood, catalog, silencing, data, macrophage, efferocytosis, treatment, expression, incubated, targeting, delivery, study, injection, injected, stability, lesions, atherosclerosis, sicamkg, gene, serum, analysis, mertk, increased, uptake, wdfed, intravenously, mouse,
Topics {✒️}
org/cgi/content/full/12/553/eaay1063/dc1 view/request 2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[maleimide dspe-peg-s2p/dspe-peg hybrids dana-farber/harvard cancer center matrix-specific protein kinase dspe-peg-s2p/dspe-peg ratios twelve-week wd-fed ldlr−/− internalized s2p50-dy647-sirna nps plaque-destabilizing molecule—camkiiγ s2p peptide–conjugated lipid-peg dy647-sirna–loaded s2p50 nps form sirna/g0-c14 complexes enzyme-linked immunosorbent assay s2p50-sicamk2g np–treated macrophages systemic nanoparticle-mediated delivery male c57bl/6j mice bone marrow–derived macrophages free dy647-labeled sirna pro-atherogenic macrophage pathways single-walled carbon nanotubes plaque macrophage–targeting peptide light-activated theranostic nanoagent pmc beta search sirna/c0-c14 complexes sicamk2g-loaded s2p50 nps lyz2cre camk2gfl/fl mice robust stabilin-2–dependent uptake shapiro-wilk normality testing np-based specific delivery stabilin-2-specific peptide ligand wd-fed ldlr−/− mice nontargeted s2p0-sicamk2g nps g0-c14/sirna complexes macrophage-targeted sicamk2g nps fluorescence-activated cell sorting β-actin [horseradish peroxidase sirna-loaded s2p50 nps targeted s2p50-sicamk2g nps siluc-loaded s2p50 nps week wd-fed ldlr−/− long-circulating sirna nanoparticles s2p50-siluc nps led fat-fed ldlr−/− mice s2p50-dy647-sirna nps nuclease-free hypure water long-term toxicity studies s2p-conjugated sirna nps nanoparticle-mediated delivery rnai-mediated gene silencing np-treated ldlr−/− mice
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