We are analyzing https://link.springer.com/article/10.1007/s11596-023-2818-2.

Title:
Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives | Current Medical Science
Description:
Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, atherosclerosis, cells, biol, vascular, stem, res, chen, endothelial, muscle, smooth, med, zhang, wang, extracellular, ads, mol, ferroptosis, sci, atherosclerotic, death, nanoparticles, mesenchymal, formation, human, thromb, macrophages, macrophage, inflammation, mice, signaling, pathway, pyroptosis, int, plaque, yang, nat, cardiovasc, traps, immunol, arterioscler, vasc, neutrophil, liu,

Topics {✒️}

mir-21-3p/pten-mediated vsmc migration wnt3a-mediated rho/rock/jnk signaling suppressing tlr4/nf-κb/stat3 activation fzd5/wnt/β-catenin pathway mir-125a-5p/tet2 pathway m1-macrophage-derived foam cells lncrna nexn-as1/nexn pathway ccaat/enhancer-binding protein beta tlr4/nf-κb signaling pathway exosomal mir-30d-5p lncrna/circrna-mirna-mrna axis cheng chen & yue-jin yang ask1/jnk/p38 mapk pathway targeting microrna-139-3p/stat1 pathway genetically-modified stem cell article download pdf advanced glycation end-products ox-ldl-induced inflammation oxidized low-density lipoprotein regulating ptp1b/pi3k/akt pathway aggregated low-density lipoprotein stem cell-based therapies ox-ldl-treated huvecs dense low-density lipoprotein z-vad-fmk-induced nuclear s-nitrosylation defines oxldl-induced mmp-2 production /ros/p38 mapk/adam17 pathway solving ischemia-reperfusion injury klf4-dependent phenotypic modulation von köckritz-blickwede von ungern-sternberg sn hyperlipid diet-induced ferroptosis copper-induced cell death extracellular traps derived mir-361/sqstm1/nlrp3 signaling microrna-615-5p regulates angiogenesis canonical nf-κb pathway p53-mediated tumour suppression apoe-deficient bone marrow ampk/mtor-dependent effects circulating mirna profiles nanoparticle-mediated rna interference chitosan-coated insulin liposomes reverses m2 polarization cyclic gmp-amp synthase neutrophil extracellular traps goblet cell-targeting nanoparticles notch-dependent mechanisms common ldl receptor-knockout mice

Questions {❓}

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?

Schema {🗺️}

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         description:Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.
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      headline:Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives
      description:Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells, which is documented as the traditional cellular paradigm. However, the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis, transdifferentiation and novel cell death forms such as ferroptosis, pyroptosis, and extracellular trap were reported. Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets. On the other side, the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden. Stem cell- or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects. Given the complexity of pathological changes of AS, attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging. In this review, the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation. The future challenges and improvements were also discussed.
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      name:State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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