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Title:
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy | Naunyn-Schmiedeberg's Archives of Pharmacology
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One of the most common tumors is hepatocellular carcinoma (HCC), and the prognosis for late-stage HCC is still not good. It is anticipated that improved outcomes would result from a deeper comprehension of the pathophysiology of HCC. Ferroptosis as a new discovered cell death type is linked to the progression of HCC and may be crucial for its detection, prevention, therapy, and prognosis. Numerous studies suggest that epigenetic alterations mediated by non-coding RNAs (ncRNA) might influence cancer cell susceptibility to ferroptosis. This study elucidates the processes of ferroptosis and delineates the paths by which ncRNAs influence HCC by modulating ferroptosis. Furthermore, it offers significant insights into ferroptosis-associated ncRNAs, intending to discover novel therapeutic approaches for HCC. It also explores innovative concepts for the future use of ncRNA-based ferroptosis-targeted therapeutics.
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28 years and 1 months (reg. 1997-05-29).
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Keywords {🔍}
pubmed, google, scholar, cas, ferroptosis, central, carcinoma, cancer, hepatocellular, wang, cell, zhang, liu, liver, death, chen, cells, noncoding, rna, role, rnas, mol, article, therapy, front, biol, hcc, int, huang, targeting, tumor, protein, sci, tang, zhou, med, long, factor, treatment, pharmacol, res, oncol, axis, therapeutic, sun, resistance, sorafenib, jiang, patients, promotes,
Topics {✒️}
lncrna h19/mir-19b-3p/fth1 axis targeting lncrna pvt1/mir-214–3p/gpx4 mir-455-3p/nupr1/fth1 axis hsa-mir-199a-5p panel p62-keap1-nrf2 pathway protects puerarin-loaded peg-pe micelles targeting mir-382-5p/slc7a11 axis glutamate-cysteine ligase inhibitors nrf1/ran/dld protein complex single-cell rna sequencing mir-541-3p/gpx4 axis month download article/chapter ncrna-based ferroptosis-targeted therapeutics mir-362-3p/miox axis mir-3200-5p/atf4 axis circ0097009/mir-1261/slc7a11 axis adsorbing mir-450b-5p exosomal mir-142-3p secreted multi-omic analysis reveals ferroptosis-related gene signature mir-654-5p promote ferroptosis suppresses sorafenib-induced ferroptosis mir-21-5p inhibits ferroptosis jak1/stat3 signaling pathway enhanced anti-apoptotic effect enhances anti-pd1 immunotherapy small-cell lung cancer microrna-670-3p suppresses ferroptosis el-aziz mka cancer-related immune functions akt/mtor signaling pathway egyptian fibrotic/cirrhotic patients promising diagnostic/prognostic biomarker dendritic-cell-targeting virus virus–related hepatocellular carcinoma nrf2/ho-1 axis mir-590-3p sponge hsa-mir-21–5p hsa-mir-192–5p hsa-mir-155–5p tfr1-dependent manner el mesallamy ho oncogenic kras protein privacy choices/manage cookies rna interference promotes iron-dependent form lncrna gabpb1-as1 avert sorafenib resistance alleviate sorafenib resistance silencing op18/stathmin
Questions {❓}
- Bhangui P (2024) Liver transplantation and resection in patients with hepatocellular cancer and portal vein tumor thrombosis: Feasible and effective?
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description:One of the most common tumors is hepatocellular carcinoma (HCC), and the prognosis for late-stage HCC is still not good. It is anticipated that improved outcomes would result from a deeper comprehension of the pathophysiology of HCC. Ferroptosis as a new discovered cell death type is linked to the progression of HCC and may be crucial for its detection, prevention, therapy, and prognosis. Numerous studies suggest that epigenetic alterations mediated by non-coding RNAs (ncRNA) might influence cancer cell susceptibility to ferroptosis. This study elucidates the processes of ferroptosis and delineates the paths by which ncRNAs influence HCC by modulating ferroptosis. Furthermore, it offers significant insights into ferroptosis-associated ncRNAs, intending to discover novel therapeutic approaches for HCC. It also explores innovative concepts for the future use of ncRNA-based ferroptosis-targeted therapeutics.
datePublished:2025-01-16T00:00:00Z
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NcRNA
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description:One of the most common tumors is hepatocellular carcinoma (HCC), and the prognosis for late-stage HCC is still not good. It is anticipated that improved outcomes would result from a deeper comprehension of the pathophysiology of HCC. Ferroptosis as a new discovered cell death type is linked to the progression of HCC and may be crucial for its detection, prevention, therapy, and prognosis. Numerous studies suggest that epigenetic alterations mediated by non-coding RNAs (ncRNA) might influence cancer cell susceptibility to ferroptosis. This study elucidates the processes of ferroptosis and delineates the paths by which ncRNAs influence HCC by modulating ferroptosis. Furthermore, it offers significant insights into ferroptosis-associated ncRNAs, intending to discover novel therapeutic approaches for HCC. It also explores innovative concepts for the future use of ncRNA-based ferroptosis-targeted therapeutics.
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