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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s00018-023-04729-4.

Title:
Receptor tyrosine kinase inhibitors in cancer | Cellular and Molecular Life Sciences
Description:
Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression. An understanding of RTKs and the relevant signaling cascades, has enabled the development of many targeted drug therapies employing RTK inhibitors (RTKIs) some of which have entered clinical application. Here we discuss RTK structures, activation mechanisms and functions. Moreover, we cover the potential effects of combination drug therapy (including chemotherapy or immunotherapy agents with one RTKI or multiple RTKIs) especially for drug resistant cancers.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, central, receptor, tyrosine, cell, kinase, lung, resistance, oncol, res, treatment, breast, therapy, cells, med, carcinoma, mol, zhang, wang, clin, inhibitors, kinases, drug, patients, advanced, phase, cancers, therapeutic, metastatic, growth, signaling, targeting, study, sci, biol, osimertinib, inhibitor, factor, molecular, pharmacol, renal, role, drugs, target, activation,

Topics {✒️}

int/news-room/fact-sheets/detail/cancer ferlay mir-512-5p/igf1r axis granulocyte-macrophage colony-stimulating factor wbrt+egfr-tki versus wbrt month download article/chapter axl-targeting antibody-drug conjugate castration-resistant prostate cancer amir reza aref her2-targeted therapies her2-positive breast cancer mitogen-activated protein kinase sunitinib-induced ar phosphorylation sanofi-aventis deutschland gmbh flt3/aurk multikinase inhibitor egfr-targeted therapies tivozanib-nivolumab combination therapy gastro-oesophageal junction adenocarcinoma small-cell lung cancer multi-kinase angiogenesis inhibitor central nervous system dana-farber cancer institute sorafenib-resistant hepatocellular carcinoma anti-pd-1 antibody immunotherapy targeted cancer therapeutics receptor tyrosine kinase receptor tyrosine kinases overcoming met-dependent resistance tyrosine kinase inhibitors metastatic prostate cancer full article pdf tyrosine kinase inhibitor inhibiting epithelial–mesenchymal transition fatemeh rezaei-tazangi chronic myeloid leukemia targeted therapy reza vafadar zainal abidin sa piha-paul sa abl kinase inhibitors jak2 tyrosine kinase anti-cancer therapies personal data pro-angiogenic therapies chang chien cr privacy choices/manage cookies anti-angiogenic therapies tyrosine kinase receptors sounni ne renal cell carcinoma c-met signaling pathways

Questions {❓}

  • Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
  • Woo HY, Yoo SY, Heo J (2017) New chemical treatment options in second-line hepatocellular carcinoma: what to do when sorafenib fails?
  • Zhao S, Wu W, Jiang H, Ma L, Pan C, Jin C et al (2021) Selective inhibitor of the c-Met receptor tyrosine kinase in advanced hepatocellular carcinoma: no beneficial effect with the use of tivantinib?
  • Zhou Y, Wang Y, Chen H, Xu Y, Luo Y, Deng Y et al (2021) Immuno-oncology: are TAM receptors in glioblastoma friends or foes?

Schema {🗺️}

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         datePublished:2023-03-22T00:00:00Z
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      headline:Receptor tyrosine kinase inhibitors in cancer
      description:Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression. An understanding of RTKs and the relevant signaling cascades, has enabled the development of many targeted drug therapies employing RTK inhibitors (RTKIs) some of which have entered clinical application. Here we discuss RTK structures, activation mechanisms and functions. Moreover, we cover the potential effects of combination drug therapy (including chemotherapy or immunotherapy agents with one RTKI or multiple RTKIs) especially for drug resistant cancers.
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         Biochemistry
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                     name:Department of Orthopeadic Surgery, Kerman University of Medical Sciences, Kerman, Iran
                     type:PostalAddress
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                     type:PostalAddress
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      name:Hajarossadat Ghaderi
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            address:
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               type:PostalAddress
            type:Organization
      name:Sahar Palizdar
      affiliation:
            name:Islamic Azad University of Tehran East Branch
            address:
               name:Division of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Tehran East Branch, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Roya Khorram
      affiliation:
            name:Shiraz University of Medical Sciences
            address:
               name:Bone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
               type:PostalAddress
            type:Organization
      name:Reza Vafadar
      affiliation:
            name:Kerman University of Medical Sciences
            address:
               name:Department of Orthopeadic Surgery, Kerman University of Medical Sciences, Kerman, Iran
               type:PostalAddress
            type:Organization
      name:Masoud Ghanaatian
      affiliation:
            name:Université Toulouse III-Paul Sabatier
            address:
               name:Master 1 Bio-Santé-Parcours Toulouse Graduate School of Cancer, Ageing and Rejuvenation (CARe), Université Toulouse III-Paul Sabatier, Toulouse, France
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               type:PostalAddress
            type:Organization
      name:Payam Baziyar
      affiliation:
            name:Uinversity of Mazandaran
            address:
               name:Department of Molecular and Cell Biology, Faculty of Basic Science, Uinversity of Mazandaran, Babolsar, Iran
               type:PostalAddress
            type:Organization
      name:Amirhossein Ahmadi
      affiliation:
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            address:
               name:Department of Biological Science and Technology, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, Iran
               type:PostalAddress
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      email:[email protected]
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            address:
               name:Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Amir Reza Aref
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
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            name:Xsphera Biosciences
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      name:Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran
      name:Medical Branch, Islamic Azad University of Tehran, Tehran, Iran
      name:Laboratory of Regenerative and Medical Innovation, Pasteur Institute of Iran, Tehran, Iran
      name:Division of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Tehran East Branch, Tehran, Iran
      name:Bone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
      name:Department of Orthopeadic Surgery, Kerman University of Medical Sciences, Kerman, Iran
      name:Master 1 Bio-Santé-Parcours Toulouse Graduate School of Cancer, Ageing and Rejuvenation (CARe), Université Toulouse III-Paul Sabatier, Toulouse, France
      name:Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
      name:Department of Molecular and Cell Biology, Faculty of Basic Science, Uinversity of Mazandaran, Babolsar, Iran
      name:Department of Biological Science and Technology, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, Iran
      name:Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
      name:Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
      name:Translational Medicine Group, Xsphera Biosciences, Boston, USA
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External Links {🔗}(625)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.06s.