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Receptor tyrosine kinase inhibitors in cancer | Cellular and Molecular Life Sciences
Description:
Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression. An understanding of RTKs and the relevant signaling cascades, has enabled the development of many targeted drug therapies employing RTK inhibitors (RTKIs) some of which have entered clinical application. Here we discuss RTK structures, activation mechanisms and functions. Moreover, we cover the potential effects of combination drug therapy (including chemotherapy or immunotherapy agents with one RTKI or multiple RTKIs) especially for drug resistant cancers.
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Keywords {🔍}
pubmed, article, google, scholar, cancer, cas, central, receptor, tyrosine, cell, kinase, lung, resistance, oncol, res, treatment, breast, therapy, cells, med, carcinoma, mol, zhang, wang, clin, inhibitors, kinases, drug, patients, advanced, phase, cancers, therapeutic, metastatic, growth, signaling, targeting, study, sci, biol, osimertinib, inhibitor, factor, molecular, pharmacol, renal, role, drugs, target, activation,
Topics {✒️}
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Questions {❓}
- Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
- Woo HY, Yoo SY, Heo J (2017) New chemical treatment options in second-line hepatocellular carcinoma: what to do when sorafenib fails?
- Zhao S, Wu W, Jiang H, Ma L, Pan C, Jin C et al (2021) Selective inhibitor of the c-Met receptor tyrosine kinase in advanced hepatocellular carcinoma: no beneficial effect with the use of tivantinib?
- Zhou Y, Wang Y, Chen H, Xu Y, Luo Y, Deng Y et al (2021) Immuno-oncology: are TAM receptors in glioblastoma friends or foes?
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Immune therapy
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Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref