
NCBI . NLM . NIH . GOV {
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Title[redir]:
Safety and activity of vandetanib in combination with everolimus in patients with advanced solid tumors: a phase I study - PMC
Description:
Preclinical studies suggest that combining vandetanib (VAN), a multi-tyrosine kinase inhibitor of rearranged during transfection (RET) proto-oncogene, vascular endothelial growth factor receptor (VEGFR), and epidermal growth factor receptor (EGFR), ...
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Keywords {🔍}
patients, doi, cancer, van, ret, tumor, clinical, study, therapy, molecular, scholar, cell, pubmed, google, tumors, therapeutics, pmc, drug, combination, patient, signaling, aberrations, supplementary, solid, article, mtor, inhibitors, kinase, free, response, targets, activity, receptor, resistance, number, dose, figure, pharmaceuticals, studies, pathways, trial, shown, toxicities, pathway, table, everolimus, phase, experienced, harboring, novartis,
Topics {✒️}
pi3k/akt/mtor signaling pathways compare interval-scaled variables wilcoxon rank-sum test multi-tyrosine kinase inhibitor pi3k-dependent feedback loop maximum anti-nausea regimens pmc beta search advanced/refractory solid malignancies advanced/refractory solid tumors small-cell lung cancer median progression-free survival hgf/c-met pathway grant number 133835-csdg-19-153-01-pcsm multi-targeted rtk inhibitors ret-driven preclinical models chao physician-scientist pi3k/akt/mtor inhibitors oral fda-approved agents salivary duct carcinoma pi3k/akt/mtor pathway dual pi3k/mtor inhibitors consultant/advisory board member primary oncogenic signal targeting ret-driven cancers receptor tyrosine kinases inhibits downstream signaling b-cell lymphoma khalifa scholars award publisher site pdf research funding/grant support dose-escalation study demonstrated cell-based studies suggest investigator-initiated nonrandomized multikinase ret inhibitor common g3-g4 toxicities advanced solid cancers rutgers cancer institute egf receptor signaling small molecule inhibitor current fda-approved dose downstream signaling pathways nat rev cancer license information pmcid advanced solid tumors akt signaling pathways required dose modifications guide future investigations pi3k/akt pathways renal cell carcinoma inhibiting ret signaling
Questions {❓}
- Dual PI3K/mTOR inhibitors: does p53 modulate response?
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