We are analyzing https://link.springer.com/article/10.1007/s00018-019-03011-w.

Title:
The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD) | Cellular and Molecular Life Sciences
Description:
NAFLD is currently the main cause of chronic liver disease in developed countries, and the number of NAFLD patients is growing worldwide. NAFLD often has similar symptoms to other metabolic disorders, including type 2 diabetes and obesity. Recently, the role of the gut microbiota in the pathophysiology of many diseases has been revealed. Regarding NAFLD, experiments using gut microbiota transplants to germ-free animal models showed that fatty liver disease development is determined by gut bacteria. Moreover, the perturbation of the composition of the gut microbiota has been observed in patients suffering from NAFLD. Numerous mechanisms relating the gut microbiome to NAFLD have been proposed, including the dysbiosis-induced dysregulation of gut endothelial barrier function that allows for the translocation of bacterial components and leads to hepatic inflammation. In addition, the various metabolites produced by the gut microbiota may impact the liver and thus modulate NAFLD susceptibility. Therefore, the manipulation of the gut microbiome by probiotics, prebiotics or synbiotics was shown to improve liver phenotype in NAFLD patients as well as in rodent models. Hence, further knowledge about the interactions among dysbiosis, environmental factors, and diet and their impacts on the gut–liver axis can improve the treatment of this life-threatening liver disease and its related disorders.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, liver, gut, microbiota, nonalcoholic, disease, central, fatty, mice, nutr, intestinal, patients, steatohepatitis, sci, microbiome, metabolic, hepatic, wang, nafld, obesity, metabolism, zhang, human, gastroenterol, effects, chen, dietary, diet, hepatology, baltimore, gastroenterology, httpsdoiorghep, hepatol, nature, cell, fecal, host, plos, delzenne, clin, obese, physiol, role, gordon, study, httpsdoiorgs,

Topics {✒️}

germ-free c57bl/6j mice integrated meta-omics-based approach high-fat-diet-induced insulin resistance short-chain fatty-acid binding month download article/chapter short-chain fatty acids high-fat-diet induced obesity philippe gérard germ-free mice high-fat diet-fed mice xenobiotics-induced liver injury tauro-beta-muricholic acid immune-mediated liver injury life-threatening liver disease lipid profile cardio-metabolic risk factors receptor-4 mediates obesity-induced integrative view abd el-bary mm fructose-induced hepatic steatosis x-box binding protein-1 altered intestinal permeability virus-related decompensated cirrhosis author information authors full article pdf dysbiosis-induced dysregulation increased intestinal permeability fecal microbiota transplantation article safari metagenome-wide association study placebo-controlled pilot study metabolic syndrome metabolic profiling reveals chronic liver disease fatty liver accompanies bile acid metabolism liver disease severity randomised clinical trial fatty liver phenotype high-fat diet innate immune signaling fatty acid oxidative fecal microbial communities privacy choices/manage cookies placebo-controlled trial regulates fat storage antibiotics protect dallinga-thie gm diet-induced obesity check access

Questions {❓}

Day CP, James OF (1998) Steatohepatitis: a tale of two “hits”?
Zatloukal K, French SW, Stumptner C, Strnad P, Harada M, Toivola DM, Cadrin M, Omary MB (2007) From Mallory to Mallory-Denk bodies: what, how and why?

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