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Title[redir]:
Hepatology
Description:
-mutant (C3H/HeJ) mice and wildtype (C3H/HouJ) mice were either fed plain water or water enriched with 30% fructose for 8 weeks. Hepatic steatosis, plasma alanine aminotransferase (ALT), and markers of insulin resistance as well as portal endotoxin levels were determined. Hepatic levels of myeloid differentiation factor 88 (MyD88), interferon regulatory factor (IRF) 3 and 7, and tumor necrosis factor alpha (TNFα) as well as markers of lipid peroxidation were assessed. Chronic intake of 30% fructose solution caused a significant increase in hepatic steatosis and plasma ALT levels in wildtype animals in comparison to water controls. In fructose-fed TLR-4 mutant mice, hepatic triglyceride accumulation was significantly reduced by ≈40% in comparison to fructose-fed wildtype mice and plasma ALT levels were at the level of water-fed controls. No difference in portal endotoxin concentration between fructose-fed wildtype and TLR-4-mutant animals was detected. In contrast, hepatic lipid peroxidation, MyD88, and TNFα levels were significantly decreased in fructose-fed TLR-4-mutant mice in comparison to fructose-fed wildtype mice, whereas IRF3 and IRF7 expression remained unchanged. Markers of insulin resistance (e.g., plasma TNFα, retinol binding protein 4, and hepatic phospho-AKT) were only altered in fructose-fed wildtype animals. Conclusion: Taken together, these data further support the hypothesis that in mice the onset of fructose-induced NAFLD is associated with intestinal bacterial overgrowth and increased intestinal permeability, subsequently leading to an endotoxin-dependent activation of hepatic Kupffer cells. (Hepatology 2009.)...
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Keywords {🔍}
hepatic, mice, liver, wildtype, fructosefed, aasld, levels, hepatology, log, journal, plasma, access, disease, subscribe, issue, alerts, abstract, fructoseinduced, steatosis, fructose, nafld, endotoxin, water, alt, markers, factor, irf, tnfα, animals, comparison, register, member, logo, browse, submit, article, tolllike, receptor, buy, intake, gutderived, role, onset, tlr, mutant, aminotransferase, insulin, resistance, portal, myd,
Topics {✒️}
fructose-fed tlr-4-mutant mice aasld members log fructose-fed wildtype animals fructose-fed wildtype mice fructose-induced hepatic steatosis open access policy endotoxin-dependent activation fructose-fed wildtype individual subscribers log tlr-4-mutant animals liver diseases fed plain water interferon regulatory factor institutional users access hepatic triglyceride accumulation hepatic phospho-akt hepatic kupffer cells dietary fructose intake gut-derived endotoxemia gut-derived endotoxin portal endotoxin concentration intestinal bacterial overgrowth increased intestinal permeability read ornithine aminotransferase artificial intelligence training water-fed controls fructose-induced nafld plasma alanine aminotransferase portal endotoxin levels full text access hepatic lipid peroxidation plasma alt levels steatohepatitis induced journal tables register subscribe 23122 buy abstract hepatology 2009 service request 800-638-3030 wildtype animals hepatic steatosis hepatic levels lipid peroxidation water controls mice† spruss mice probiotics journal website subscribe water enriched chronic intake plasma tnfα
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