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Keywords {🔍}

skin, mice, fig, pubmed, lipid, article, diet, scholar, google, lipids, data, skins, cas, fat, supplementary, dietary, epidermis, adipose, sebome, acyl, fed, central, days, dwat, properties, heat, tissue, weeks, increased, female, hair, consumption, feeding, metabolic, energy, thermal, high, body, shown, nature, total, function, epidermal, cell, hfd, cbl, ceramides, specific, species, wdil,

Topics {✒️}

nature portfolio author information authors peer review file privacy policy lc/q-tof mass spectrometry hrp-conjugated anti-rabbit antibody references radner /scientific-software/prism data availability peer review editing sera-specific libraries proteo-lipid cross-linked sheath advertising animal ethics checklist nature 451 nature closely-apposed lipid-enriched layers social media epidermal acyl-coa-binding protein diabetes research center lower mitotic index sharing cross-linked proteolipid matrix reprints author correspondence original author e-stained skin sections lc/qtof-ms spectra branched-chain amino acids fourier-transform mass spectrometry cross-linked stratum corneum27 source data files lc/qtof-ms confirmed human subjects healthy subjects short-chain fatty acids acyl-coa-binding protein discussion skin mitotic index helpful discussion e-stained sections supplementary information long-chain fatty acids source data file low-isoleucine western diet chain-melting transition temperatures methyl tert-butyl ether keratinocyte/sebocyte-enriched tissue fraction additional assistance

Questions {❓}

• Cutaneous changes in diabetic patients: Primed for aberrant healing?
• Does skin offer a means of excess lipid disposal?
• How important is thermal adaptation of skin to insulation, energetics and metabolic health of mammals?
• Which cellular components are implicated in functional responses?
• Which lipid components correlate with altered thermal barrier function?

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