
NATURE . COM {
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Title:
Dietary lipids are largely deposited in skin and rapidly affect insulating properties | Nature Communications
Description:
Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.
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Keywords {π}
skin, mice, fig, pubmed, lipid, article, diet, scholar, google, lipids, data, skins, cas, fat, supplementary, dietary, epidermis, adipose, sebome, acyl, fed, central, days, dwat, properties, heat, tissue, weeks, increased, female, hair, consumption, feeding, metabolic, energy, thermal, high, body, shown, nature, total, function, epidermal, cell, hfd, cbl, ceramides, specific, species, wdil,
Topics {βοΈ}
nature portfolio author information authors peer review file privacy policy lc/q-tof mass spectrometry hrp-conjugated anti-rabbit antibody references radner /scientific-software/prism data availability peer review editing sera-specific libraries proteo-lipid cross-linked sheath advertising animal ethics checklist nature 451 nature closely-apposed lipid-enriched layers social media epidermal acyl-coa-binding protein diabetes research center lower mitotic index sharing cross-linked proteolipid matrix reprints author correspondence original author e-stained skin sections lc/qtof-ms spectra branched-chain amino acids fourier-transform mass spectrometry cross-linked stratum corneum27 source data files lc/qtof-ms confirmed human subjects healthy subjects short-chain fatty acids acyl-coa-binding protein discussion skin mitotic index helpful discussion e-stained sections supplementary information long-chain fatty acids source data file low-isoleucine western diet chain-melting transition temperatures methyl tert-butyl ether keratinocyte/sebocyte-enriched tissue fraction additional assistance
Questions {β}
- Cutaneous changes in diabetic patients: Primed for aberrant healing?
- Does skin offer a means of excess lipid disposal?
- How important is thermal adaptation of skin to insulation, energetics and metabolic health of mammals?
- Which cellular components are implicated in functional responses?
- Which lipid components correlate with altered thermal barrier function?
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description:Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.
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