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Title:
Dietary lipids are largely deposited in skin and rapidly affect insulating properties | Nature Communications
Description:
Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.
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Keywords {π}
skin, mice, fig, pubmed, lipid, article, diet, scholar, google, lipids, data, skins, cas, fat, dietary, supplementary, epidermis, adipose, sebome, acyl, fed, central, days, dwat, properties, heat, tissue, weeks, increased, female, hair, consumption, feeding, metabolic, energy, thermal, high, body, shown, nature, total, function, epidermal, cell, hfd, cbl, ceramides, specific, species, wdil,
Topics {βοΈ}
nature portfolio privacy policy lc/q-tof mass spectrometry hrp-conjugated anti-rabbit antibody /scientific-software/prism editing sera-specific libraries proteo-lipid cross-linked sheath advertising closely-apposed lipid-enriched layers nature 451 nature social media epidermal acyl-coa-binding protein diabetes research center lower mitotic index peer review file cross-linked proteolipid matrix reprints lc/qtof-ms spectra branched-chain amino acids fourier-transform mass spectrometry cross-linked stratum corneum27 lc/qtof-ms confirmed short-chain fatty acids acyl-coa-binding protein author information authors mitotic index long-chain fatty acids low-isoleucine western diet chain-melting transition temperatures methyl tert-butyl ether keratinocyte/sebocyte-enriched tissue fraction free access peer review poly-unsaturated acyl chains high fat-diet feeding Ξ²-adrenergic-resistant depot amino acid-defined wd health-promoting diet interventions source data files multi-modal lipid profiling imiquimod-induced psoriasiform dermatitis multi-modal lipidomic analysis wdil-fed mice resisted wdil-fed mice revealed ether-linked oxidized phosphatidylcholines cold elastase/dmem/hepes permissions multi-modal lipid analysis
Questions {β}
- Cutaneous changes in diabetic patients: Primed for aberrant healing?
- Does skin offer a means of excess lipid disposal?
- How important is thermal adaptation of skin to insulation, energetics and metabolic health of mammals?
- Which cellular components are implicated in functional responses?
- Which lipid components correlate with altered thermal barrier function?
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description:Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.
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headline:Dietary lipids are largely deposited in skin and rapidly affect insulating properties
description:Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.
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