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gpd, cells, crc, oxaliplatin, cell, pubmed, article, cancer, figure, expression, knockdown, google, scholar, ros, cas, analysis, treatment, apoptosis, dld, hct, nadph, levels, tumor, treated, high, increased, enhances, colorectal, patients, nature, redox, pdx, cellular, supplementary, polyplexes, homeostasis, models, therapeutic, study, tissues, control, central, activity, staining, group, mice, data, oxaliplatininduced, gene, sensitivity,

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nature portfolio pvt1/mir-195-5p axis-dependent manner privacy policy nature bisecting glcnac-branched n-glycosylation advertising apoptotic index nadph/nadp-glo assay kit sun yat-sen university social media glucose-6-phosphate dehydrogenase expression gsh/gssg-glo assay kit enhances oxaliplatin-induced apoptosis 0/ reprints g6pd-mediated nadph homeostasis hbx-mediated nrf2 activation singlet oxygen-induced apoptosis glucose-6-phosphate dehydrogenase full size image block epithelial-mesenchymal transition platinum-based antineoplastic agent g6pd-mediated antioxidant production cell line-based xenografts c-src facilitates tumorigenesis rapid-developing field recently rate-limiting enzyme g6pd oxaliplatin-induced apoptotic cells nrf2-mediated antioxidant response student unpaired t-test log-phase g6pd knockdown pentose phosphate pathway cell line-based experiments permissions biosynthesis redox homeostasis progression-free survival curves selectively kills kras previously published reports g6pd-knockdown crc cells sorafenib induced ferroptosis g6pd-knockdown cells compared oxaliplatin-induced cytotoxicity original magnification anti-proliferative effects providing ribose phosphate induced significant increase gsh/gssg ratios potential-sensitive probe rhodamine-123 ros-mediated damage lowers gsh levels nedd8 pathway inhibition

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• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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      name:Q-N Wu
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:J Liu
      affiliation:
            name:School of Engineering, Sun Yat-sen University
            address:
               name:Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Z-L Zeng
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:H-Y Mo
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Y Chen
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:School of Engineering, Sun Yat-sen University
            address:
               name:Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:T Tian
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Y Wang
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:T-B Kang
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:D Xie
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:M-S Zeng
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:P Huang
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:R-H Xu
      affiliation:
            name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
            address:
               name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

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