We are analyzing https://link.springer.com/article/10.1007/s11010-007-9421-x.

Title:
Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+-dependent isocitrate dehydrogenase | Molecular and Cellular Biochemistry
Description:
Singlet oxygen is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules and it also promotes deleterious processes such as cell death. Recently, we demonstrated that the control of redox balance and the cellular defense against oxidative damage are the primary functions of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) through supplying NADPH for antioxidant systems. In this report, we demonstrate that modulation of IDPc activity in HL-60 cells regulates singlet oxygen-induced apoptosis. When we examined the protective role of IDPc against singlet oxygen-induced apoptosis with HL-60 cells transfected with the cDNA for mouse IDPc in sense and antisense orientations, a clear inverse relationship was observed between the amount of IDPc expressed in target cells and their susceptibility to apoptosis. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen.
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Topics {✒️}

α-phenyl-n-t-butyl nitrone jeen-woo park month download article/chapter n-t-butyl hydroxylamine jean kyoung tak singlet oxygen-induced apoptosis kyeong sook choi glucose-6-phosphate dehydrogenase ythdf2 o-glcnac modification hl-60 cells induced glutathione-sensitive fluorescent dyes membrane-bound protoporphyrin mediated �housekeeping” enzyme subject hl-60 cells transfected kyungpook national university korea research foundation oxidative damage single extraction procedure full article pdf related subjects mitochondrial permeability transition beta-carotene therapy privacy choices/manage cookies singlet oxygen production singlet oxygen formation singlet molecular oxygen photodynamic therapy work directly operating antioxidant singlet delta dioxygen cellular biochemistry aims su min lee article kim european economic area highly reactive form promotes deleterious processes clear inverse relationship boosts antitumor efficacy chain lipid peroxidation reduced pyridine nucleotides human epidermal melanocytes reductive hotspot hypothesis human lung fibroblasts check access instant access chemico-biol interact 70 conditions privacy policy affiliations school tissue-specific regulation article molecular van henegouven gmjb

Questions {❓}

Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work?
Kirsch M, De Groot H (2001) NAD(P)H, a directly operating antioxidant?

Schema {🗺️}

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         description:Singlet oxygen is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules and it also promotes deleterious processes such as cell death. Recently, we demonstrated that the control of redox balance and the cellular defense against oxidative damage are the primary functions of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) through supplying NADPH for antioxidant systems. In this report, we demonstrate that modulation of IDPc activity in HL-60 cells regulates singlet oxygen-induced apoptosis. When we examined the protective role of IDPc against singlet oxygen-induced apoptosis with HL-60 cells transfected with the cDNA for mouse IDPc in sense and antisense orientations, a clear inverse relationship was observed between the amount of IDPc expressed in target cells and their susceptibility to apoptosis. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen.
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      description:Singlet oxygen is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules and it also promotes deleterious processes such as cell death. Recently, we demonstrated that the control of redox balance and the cellular defense against oxidative damage are the primary functions of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) through supplying NADPH for antioxidant systems. In this report, we demonstrate that modulation of IDPc activity in HL-60 cells regulates singlet oxygen-induced apoptosis. When we examined the protective role of IDPc against singlet oxygen-induced apoptosis with HL-60 cells transfected with the cDNA for mouse IDPc in sense and antisense orientations, a clear inverse relationship was observed between the amount of IDPc expressed in target cells and their susceptibility to apoptosis. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen.
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