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Neurobiology of food intake in health and disease | Nature Reviews Neuroscience
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The energy homeostasis system maintains stability of body fat stores over time but can be overridden by activation of feeding neurocircuits during emergent or stressful conditions. In this Review, Schwartz and colleagues highlight crosstalk between homeostatic and emergency feeding circuits in the regulation of energy balance. Under normal conditions, food intake and energy expenditure are balanced by a homeostatic system that maintains stability of body fat content over time. However, this homeostatic system can be overridden by the activation of
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nature portfolio permissions reprints privacy policy body mass index diabetes research center advertising author information authors regional brain response medical research service sandra social media author correspondence hypothalamic ikkΞ²/nf-ΞΊb arcuate pro-opiomelanocortin neurons palatable high-fat diets insulin activates atp-sensitive physical activity decision-making central leptin infusion atp-sensitive potassium channels fat-rich diet activates cck-induced meal suppression emergency-activated circuits interact personal data serum immunoreactive-leptin concentrations high-fat feeding underlies central hormone resistance body fat content springerlink instant access hypothalamic paraventricular nucleus pro-opiomelanocortin neurons oxytocin-deficient mice data protection fasting-activated hypothalamic neurons long-term orexigenic effects lean-body-mass composition 2-deoxy-d-glucose administration central neural networks obesity-related insulin resistance streptozotocin-induced diabetic rats normal body-weight homeostasis nature genet oxytocin inhibits food nature neurosci express pro-opiomelanocortin nature med nature rev increases food intake early-onset obesity agouti-related protein diet-induced obese rats
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The energy homeostasis system maintains stability of body fat stores over time but can be overridden by activation of feeding neurocircuits during emergent or stressful conditions. In this Review, Schwartz and colleagues highlight crosstalk between homeostatic and emergency feeding circuits in the regulation of energy balance. Under normal conditions, food intake and energy expenditure are balanced by a homeostatic system that maintains stability of body fat content over time. However, this homeostatic system can be overridden by the activation of 'emergency response circuits' that mediate feeding responses to emergent or stressful stimuli. Inhibition of these circuits is therefore permissive for normal energy homeostasis to occur, and their chronic activation can cause profound, even life-threatening, changes in body fat mass. This Review highlights how the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions.
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