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Title[redir]:
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis - PMC
Description:
Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors are attractive pharmacological targets for the treatment of obesity; however, the identity of the serotonin 2C receptorโexpressing neurons that mediate ...
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Keywords {๐}
mice, serotonin, doi, neurons, cflox, pomc, pomccre, figure, glucose, receptors, body, pubmed, google, scholar, receptor, diet, data, energy, weight, hfhs, chowfed, insulin, pomccreert, homeostasis, control, pmc, article, blood, glucagon, food, levels, mouse, intake, central, htrc, free, loss, dfen, results, weeks, obesity, versus, metabolic, tamoxifen, mcpp, cfloxy, hfhsfed, hour, effects, signaling,
Topics {โ๏ธ}
cre-conditional htr2c-null allele ligand-activated site-specific recombination obesigenic high-fat/high-sugar high-fat/high-sugar diet lox-modified htr2c-targeting plasmid 129x1/svj mouse strain centrally-acting anti-obesity drugs 5-hour-fasted chow-fed conditions tamoxifen-inducible pomc-cre system fat-feeding-induced insulin resistance enriched c57bl/6j background enable adult-onset deletion serotonin-immunoreactive nerve terminals induce adult-onset loss 24-hour overnight-fasted mice 12-hour overnight-fasted mice induce adult-onset ablation lox-modified htr2c dna cre-activated reporter expression constitutive pomc-cre mice acutely hfhs-fed mice body htr2c-null mice seizure-induced death reported pmc beta search chow-fed body weight cre-dependent reporter tdtomato inducible pomc-cre model serotonin 2c receptor arcuate pro-opiomelanocortin neurons impaired insulin-mediated suppression body htr2c-null progeny pmc copyright notice insulin-stimulated glucose turnover serotonergic anti-obesity agents maximum glucagon-stimulated contribution insulin-stimulated endo ra supplementary materials included 12-hour overnight-fasted downstream melanocortin pathways methods animal care serotonin 2c receptors serotonin receptor isoforms greater hfhs-induced obesity performed hyperinsulinemic-euglycemic clamps leptin receptor signaling hyperinsulinemic-euglycemic clamp studies adult-onset loss hfhs-fed control genotypes 5-hour-fasted cohorts chow-fed cohorts
Questions {โ}
- The use of serotonergic drugs to treat obesity โ is there any hope?
- What is the prognosis for new centrally-acting anti-obesity drugs?
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Analytics and Tracking {๐}
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