We are analyzing https://link.springer.com/article/10.1007/s13539-010-0015-1.

Title:
Pathophysiology and treatment of inflammatory anorexia in chronic disease | Journal of Cachexia, Sarcopenia and Muscle
Description:
Decreased appetite and involuntary weight loss are common occurrences in chronic disease and have a negative impact on both quality of life and eventual mortality. Weight loss in chronic disease comes from both fat and lean mass, and is known as cachexia. Both alterations in appetite and body weight loss occur in a wide variety of diseases, including cancer, heart failure, renal failure, chronic obstructive pulmonary disease and HIV. An increase in circulating inflammatory cytokines has been implicated as a uniting pathogenic mechanism of cachexia and associated anorexia. One of the targets of inflammatory mediators is the central nervous system, and in particular feeding centers in the hypothalamus located in the ventral diencephalon. Current research has begun to elucidate the mechanisms by which inflammation reaches the hypothalamus, and the neural substrates underlying inflammatory anorexia. Research into these neural mechanisms has suggested new therapeutic possibilities, which have produced promising results in preclinical and clinical trials. This review will discuss inflammatory signaling in the hypothalamus that mediates anorexia, and the opportunities for therapeutic intervention that these mechanisms present.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

google, scholar, pubmed, cas, article, anorexia, cachexia, inflammatory, cancer, ghrelin, chronic, intake, neurons, cytokines, food, patients, melanocortin, signaling, cytokine, levels, npy, brain, tumor, administration, response, animals, hypothalamic, mice, effects, tumorbearing, receptor, leptin, weight, loss, studies, rats, central, increased, lps, anorectic, mass, failure, interleukin, muscle, disease, energy, ilβ, hypothalamus, multiple, peripheral,

Topics {✒️}

alpha-melanocyte stimulating hormone stress-related neuroendocrine circuitry tumor necrosis factor-alpha article download pdf cells/leukemia inhibitory factor nuclear factor-kappab activation plata-salamán cr small-cell lung cancer lipopolysaccharide-induced anorexia depends body-cell-mass depletion agouti-related protein immunoreactivity blood-cerebrospinal fluid barrier intramedullary prostaglandin-dependent mechanism tumor-bearing animals show post-injection food intake tumor-bearing animals resulted anorectic tumor-bearing rats stimulating agrp/npy neurons wild-type anorexic mice agouti-related peptide/neuropeptide murine blood-brain barrier il-1 beta-induced anorexia c-fos mrna induced il-1β-induced anorexia left ventricular dysfunction leukemia inhibitory factor open access license tumor necrosis factor improve food intake skeletal muscle hypertrophy peripheral anti-catabolic effects attenuate cytokine-induced anorexia agouti-related protein normal body-weight homeostasis privacy choices/manage cookies reduce cancer-induced cachexia il-1β mrna expression hypothalamic agrp/npy neurons orexigenic agrp/npy neurons leukaemia inhibitory factor banks wa pro-opiomelanocortin processing npy-induced feeding response improves food intake bioactive products including cancer-related anorexia/cachexia murine il-1 alpha ameliorates anorexia induced peripheral interleukin-1beta administration tumor-bearing mice [90

Questions {❓}

Differential leptin access into the brain–a hierarchical organization of hypothalamic leptin target sites?
Y eat?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pathophysiology and treatment of inflammatory anorexia in chronic disease
         description:Decreased appetite and involuntary weight loss are common occurrences in chronic disease and have a negative impact on both quality of life and eventual mortality. Weight loss in chronic disease comes from both fat and lean mass, and is known as cachexia. Both alterations in appetite and body weight loss occur in a wide variety of diseases, including cancer, heart failure, renal failure, chronic obstructive pulmonary disease and HIV. An increase in circulating inflammatory cytokines has been implicated as a uniting pathogenic mechanism of cachexia and associated anorexia. One of the targets of inflammatory mediators is the central nervous system, and in particular feeding centers in the hypothalamus located in the ventral diencephalon. Current research has begun to elucidate the mechanisms by which inflammation reaches the hypothalamus, and the neural substrates underlying inflammatory anorexia. Research into these neural mechanisms has suggested new therapeutic possibilities, which have produced promising results in preclinical and clinical trials. This review will discuss inflammatory signaling in the hypothalamus that mediates anorexia, and the opportunities for therapeutic intervention that these mechanisms present.
         datePublished:2010-12-17T00:00:00Z
         dateModified:2010-12-17T00:00:00Z
         pageStart:135
         pageEnd:145
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s13539-010-0015-1
         keywords:
            Cachexia
            Anorexia
            Hypothalamus
            Inflammation
            Melanocortin
            Internal Medicine
            Oncology
            Geriatrics/Gerontology
            Clinical Nutrition
            Molecular Medicine
            Pharmacology/Toxicology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13539-010-0015-1/MediaObjects/13539_2010_15_Fig1_HTML.gif
         isPartOf:
            name:Journal of Cachexia, Sarcopenia and Muscle
            issn:
               2190-6009
               2190-5991
            volumeNumber:1
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Theodore P. Braun
               affiliation:
                     name:Oregon Health and Sciences University
                     address:
                        name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel L. Marks
               affiliation:
                     name:Oregon Health and Sciences University
                     address:
                        name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pathophysiology and treatment of inflammatory anorexia in chronic disease
      description:Decreased appetite and involuntary weight loss are common occurrences in chronic disease and have a negative impact on both quality of life and eventual mortality. Weight loss in chronic disease comes from both fat and lean mass, and is known as cachexia. Both alterations in appetite and body weight loss occur in a wide variety of diseases, including cancer, heart failure, renal failure, chronic obstructive pulmonary disease and HIV. An increase in circulating inflammatory cytokines has been implicated as a uniting pathogenic mechanism of cachexia and associated anorexia. One of the targets of inflammatory mediators is the central nervous system, and in particular feeding centers in the hypothalamus located in the ventral diencephalon. Current research has begun to elucidate the mechanisms by which inflammation reaches the hypothalamus, and the neural substrates underlying inflammatory anorexia. Research into these neural mechanisms has suggested new therapeutic possibilities, which have produced promising results in preclinical and clinical trials. This review will discuss inflammatory signaling in the hypothalamus that mediates anorexia, and the opportunities for therapeutic intervention that these mechanisms present.
      datePublished:2010-12-17T00:00:00Z
      dateModified:2010-12-17T00:00:00Z
      pageStart:135
      pageEnd:145
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s13539-010-0015-1
      keywords:
         Cachexia
         Anorexia
         Hypothalamus
         Inflammation
         Melanocortin
         Internal Medicine
         Oncology
         Geriatrics/Gerontology
         Clinical Nutrition
         Molecular Medicine
         Pharmacology/Toxicology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13539-010-0015-1/MediaObjects/13539_2010_15_Fig1_HTML.gif
      isPartOf:
         name:Journal of Cachexia, Sarcopenia and Muscle
         issn:
            2190-6009
            2190-5991
         volumeNumber:1
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Theodore P. Braun
            affiliation:
                  name:Oregon Health and Sciences University
                  address:
                     name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel L. Marks
            affiliation:
                  name:Oregon Health and Sciences University
                  address:
                     name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Cachexia, Sarcopenia and Muscle
      issn:
         2190-6009
         2190-5991
      volumeNumber:1
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Oregon Health and Sciences University
      address:
         name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
         type:PostalAddress
      name:Oregon Health and Sciences University
      address:
         name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Theodore P. Braun
      affiliation:
            name:Oregon Health and Sciences University
            address:
               name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
               type:PostalAddress
            type:Organization
      name:Daniel L. Marks
      affiliation:
            name:Oregon Health and Sciences University
            address:
               name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA
      name:Department of Pediatrics, Oregon Health and Sciences University, Portland, USA

External Links {🔗}(419)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

9.61s.

LINK . SPRINGER . COM {}