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We are analyzing https://www.nature.com/articles/nrmicro2070.

Title:
Pyroptosis: host cell death and inflammation | Nature Reviews Microbiology
Description:
Microorganism- and host-derived signals can stimulate formation of a multiprotein complex called the inflammasome, which activates the cysteine protease caspase 1. In turn, caspase 1 triggers an inflammatory programmed cell death pathway known as pyroptosis. Numerous pathogens have evolved a mechanism to subvert pyroptosis and persist within infected cells. Eukaryotic cells can initiate several distinct programmes of self-destruction, and the nature of the cell death process (non-inflammatory or proinflammatory) instructs responses of neighbouring cells, which in turn dictates important systemic physiological outcomes. Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by various pathological stimuli, such as stroke, heart attack or cancer, and is crucial for controlling microbial infections. Pathogens have evolved mechanisms to inhibit pyroptosis, enhancing their ability to persist and cause disease. Ultimately, there is a competition between host and pathogen to regulate pyroptosis, and the outcome dictates life or death of the host.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Telecommunications
  • Science

Content Management System {📝}

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Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

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Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
Our estimates place Nature.com's monthly online earnings from display ads at $354,480 to $974,820.

Keywords {🔍}

pubmed, article, google, scholar, cas, cell, caspase, activation, central, death, nature, inflammasome, immunol, infection, pyroptosis, apoptosis, host, macrophages, microbiol, cells, inflammatory, biol, protein, cookson, interleukin, salmonella, usa, dependent, immunity, inflammation, interleukinβ, ilβ, release, access, macrophage, sci, chem, proc, natl, acad, secretion, response, role, infect, immun, caspasedependent, exp, med, ipaf, content,

Topics {✒️}

permissions reprints nature portfolio privacy policy key pyroptosis-related genes advertising anaplasma phagocytophilum infection social media author information authors candida albicans conserved carboxy-terminal domain leucine-rich repeat domain human monocyte-derived macrophages inflammasome components cias1/cryopyrin/nlrp3 alarm-ringing inflammatory recruitment caspase-1-dependent pore formation nigericin-induced interleukin-1β release il-1β-converting enzyme author correspondence interleukin 1β-converting enzyme n-end rule pathway murine phospho-mlkl-s345 nature rev il-1β-loaded microvesicles nature genet pro-inflammatory il-1β pathogen-induced cell death dye uptake-independent pathway naip5-mediated macrophage immunity salmonella-induced caspase-2 activation personal data il-18/ifn-γ axis endolysosome-related vesicles nature immunol shigella flexneri-induced apoptosis shigella flexneri-induced inflammation outcome dictates life springerlink instant access inflammatory cytokines interleukin-1β data protection permissions nature nature 440 nature 452 nature 430 nature 399 nature 425 nature 453 human dendritic cells pseudomonas aeruginosa mediated nf-κb activation

Questions {❓}

  • Apoptosis: who was first?
  • Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

Schema {🗺️}

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