
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Autophagy is an immediate macrophage response to Legionella pneumophila - PMC
Description:
After ingestion by macrophages, Legionella pneumophila enter spacious vacuoles that are quickly enveloped by endoplasmic reticulum (ER), then slowly transferred to lysosomes. Here we demonstrate that the macrophage autophagy machinery recognizes the ...
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Keywords {🔍}
legionella, doi, macrophages, autophagy, pubmed, google, scholar, vacuoles, atg, fig, infection, pmc, cell, swanson, article, free, autophagosomes, autophagosome, pathway, protein, phagosomes, bacteria, cells, pneumophila, mdc, min, mice, formation, membrane, macrophage, lysosomes, isberg, infected, amer, cbl, maturation, bars, biol, intracellular, dota, pathogen, enzyme, naip, roy, phagosome, rapamycin, machinery, replication, vacuole, vesicles,
Topics {✒️}
c-shaped atg7-labelled structures gonçalves da costa amino acid-free buffer lipid-raft-rich spacious vacuole cell-free supernatant prepared pmc beta search dot/icm virulence system short-lived spacious phagosomes multiple atg8-labelled vesicles dominant-interfering snare proteins post-exponential wild-type leupeptin-administered rat liver caveolin-enriched membrane domains blood-stage plasmodium chabaudi nucleation-assembly elongation process dot/icm system legionella–macrophage interactions provide cell microbiol summary autophagic/lysosomal protein degradation lysosomal lamp-1-positive compartments references abu kwaik protein-activating enzyme essential inhibits phagosome-lysosome fusion numerous atg8-positive vacuoles double-membrane er envelope pi3-kinases dot/icm mutants autophagy-initiating enzyme atg7 acquire lysosomal features rabbit anti-atg8/lc3 roisin-bouffay phosphatidylinositol kinase homologue publisher site pdf yeast autophagy-related genes mdc-positive bacterial vacuoles legionella-permissive naip5 mutant pathogen-induced vacuoles matured percentage atg7-positive phagosomes autophagosome-stimulating factor major catabolic pathway early secretory system amino acid deprivation lipid raft vacuoles vacuoles harbouring legionella congenic mouse strain contained virulent legionella percentage atg8-positive phagosomes pmc disclaimer pe dota mutant atg7-labelled vacuoles
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