
NCBI . NLM . NIH . GOV {
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Title[redir]:
Microbial Pathogen-Induced Necrotic Cell Death Mediated by the Inflammasome Components CIAS1/Cryopyrin/NLRP3 and ASC - PMC
Description:
Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1βproduction. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1β secretion. ...
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Keywords {🔍}
cell, death, doi, cells, cryopyrin, pubmed, google, scholar, ilβ, asc, caspase, figure, cias, diseaseassociated, release, shigella, flexneri, necrosis, thp, response, macrophages, pmc, article, hmgb, protein, apoptosis, free, results, infection, expression, wildtype, activation, independent, infected, bacteria, mutant, data, caused, mutants, measured, host, inflammasome, necroticlike, patients, flexneriinduced, process, proteins, induced, apoptotic, induce,
Topics {✒️}
cias1/cryopyrin/pypaf1/nalp3/cat-erpiller 1 card4/nod1 mediates nf-kappab bone marrow-derived macrophages mutant-cryopyrin-induced cell death sense pathogen-derived products flexneri-induced il-1β release /cgi/content/full/2/3/147/dc1/ nb-lrr proteins respond pmc beta search abrogated mutant-cryopyrin-induced release hrp-conjugated secondary antibodies proteins called nb-lrrs regular anti-inflammatory medications cleaves pro-il-1β shigella-mediated cell death wild-type cryopyrin plays excessive il-1β production monocytic/macrophage cell types excessive il-1β secretion mutant-cryopyrin-induced death cryopyrin-mediated cell death shigella-induced cell death produce mature il-1β flexneri-induced cell death cryopyrin-induced cell death cell-type specific fashion serum-free media bacterial-induced cell death il-1β-mediated signaling muckle-wells autoinflammatory disorder mutant-cryopyrin-expressing cells induce il-1β production shigella-induced necrosis occurred flexneri-induced macrophage necrosis potential-sensitive dye tmre programmed pathogen-induced necrosis 200 μg/ml rn-ase flexneri-induced il-1β staurosporine-treated cells exhibit bacteria-induced cell death leucine-rich repeat domains cias1-deficient thp1 cells enhanced il-1β release n-terminal pyrin domain asc-induced cell death mice lacking nod1/card4 thioglycolate-elicited peritoneal macrophages bone marrow macrophages antibiotic-free rpmi undergone anti-inflammatory treatment
Questions {❓}
- Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death?
- Are innate immune signaling pathways in plants and animals conserved?
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- How much does https://scholar.google.com/scholar_lookup?journal=Science&title=Defective%20LPS%20signaling%20in%20C3H/HeJ%20and%20C57BL/10ScCrmMice:%20Mutations%20in%20Tlr4%20gene&author=A%20Poltorak&author=X%20He&author=I%20Smirnova&author=MY%20Liu&author=CV%20Huffel&volume=282&publication_year=1998&pages=2085-2088&pmid=9851930&doi=10.1126/science.282.5396.2085& make?
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- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Apoptosis-associated%20Speck-like%20protein%20containing%20a%20caspase%20recruitment%20domain%20is%20a%20regulator%20of%20Procaspase-1%20activation&author=C%20Stehlik&author=SH%20Lee&author=A%20Dorfleutner&author=A%20Stassinopoulos&author=J%20Sagara&volume=171&publication_year=2003&pages=6154-6163&pmid=14634131&doi=10.4049/jimmunol.171.11.6154&?
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- How much money does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=A%20novel%20caspase-1/toll-like%20receptor%204-independent%20pathway%20of%20cell%20death%20induced%20by%20cytosolic%20shigella%20in%20infected%20macrophages&author=T%20Suzuki&author=K%20Nakanishi&author=H%20Tsutsui&author=H%20Iwai&author=S%20Akira&volume=280&publication_year=2005&pages=14042-14050&pmid=15695506&doi=10.1074/jbc.M414671200& generate?
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