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We are analyzing https://www.nature.com/articles/nrm2639.

Title:
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system | Nature Reviews Molecular Cell Biology
Description:
Tie receptors and their angiopoietin ligands have important functions during embryonic vessel assembly and maturation, and control adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of these receptors and ligands provide important insights into their functions. Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls embryonic development and is also involved in numerous life-threatening human diseases. Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)–VEGF receptor system. The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. Ang–Tie signalling is essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month


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$531,700 per month
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Keywords {🔍}

pubmed, google, scholar, article, cas, angiopoietin, tie, cell, endothelial, vascular, receptor, central, cells, angiogenesis, growth, nature, res, kinase, cancer, biol, ang, blood, factor, role, expression, tumor, tyrosine, vessel, development, chem, mice, regulation, sci, usa, signalling, activation, pathway, research, access, proc, natl, acad, med, circ, information, system, ligand, kim, embryonic, survival,

Topics {✒️}

nature portfolio permissions reprints privacy policy platelet-derived growth factor-β author information authors vascular endothelial-protein-tyrosine phosphatase advertising tie2-signalling-dependent anti-permeability effects adenovirus-delivered anti-tie-2 intrabody nature cell biol biomedical research center social media nature rev national research laboratory angiopoietin/tie research pten/pi3-kinase/akt α-smooth muscle actin tools prevents endothelial-cell apoptosis receptor-tyrosine kinase tie2 nature struct author correspondence nature med fibrinogen/angiopoietin-related protein junctional cell–cell contact angiopoietin-1-mediated endothelial permeability atherosclerosis-prone vascular niches tumour-necrosis factor-α angiogenesis research supplementary information 41580_2009_bfnrm2639_moesm1_esm supplementary information s2 supplementary information s3 ang1/tie2 signaling pathway nature 376 nature 453 nature angiopoietin 1/tie2/serotonin pathway overt angiogenesis-related phenotype surrounding peri-endothelial cells vascular lineage-specific genes mannitol-induced apoptosis angiopoietin-1-dependent cell migration smooth muscle cells peri-endothelial pericyte coverage cell–substratum contacts regulated cell type-specific expression flow-dependent endothelial phenotypes receptor tyrosine kinases hematopoietic stem cells springerlink instant access

Schema {🗺️}

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         description: Tie receptors and their angiopoietin ligands have important functions during embryonic vessel assembly and maturation, and control adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of these receptors and ligands provide important insights into their functions. Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls embryonic development and is also involved in numerous life-threatening human diseases. Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)–VEGF receptor system. The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. Ang–Tie signalling is essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system.
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      headline:Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
      description: Tie receptors and their angiopoietin ligands have important functions during embryonic vessel assembly and maturation, and control adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of these receptors and ligands provide important insights into their functions. Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls embryonic development and is also involved in numerous life-threatening human diseases. Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)–VEGF receptor system. The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. Ang–Tie signalling is essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system.
      datePublished:
      dateModified:
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                  address:
                     name:Joint Research Division Vascular Biology, Medical Faculty Mannheim (CBTM), University of Heidelberg, and German Cancer Research Center Heidelberg (DKFZ–ZMBH Alliance), Germany
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               name:Joint Research Division Vascular Biology, Medical Faculty Mannheim (CBTM), University of Heidelberg, and German Cancer Research Center Heidelberg (DKFZ–ZMBH Alliance), Germany
               type:PostalAddress
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      email:[email protected]
      name:Gou Young Koh
      affiliation:
            name:National Research Laboratory of Vascular Biology and Biomedical Research Center, Korea Advanced Institute of Science and Technology
            address:
               name:Department of Biological Sciences, National Research Laboratory of Vascular Biology and Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, Korea
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      affiliation:
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            address:
               name:Department of Pathology, Molecular Cancer Biology Laboratory, Haartman Institute, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O.B. 63, Helsinki, Finland
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      name:Department of Biological Sciences, National Research Laboratory of Vascular Biology and Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, Korea
      name:Regeneron Pharmaceuticals, Tarrytown, USA
      name:Department of Pathology, Molecular Cancer Biology Laboratory, Haartman Institute, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O.B. 63, Helsinki, Finland
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