NCBI . NLM . NIH . GOV {
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Title[redir]:
Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway - PMC
Description:
Smooth muscle cell proliferation around small pulmonary vessels is essential to the pathogenesis of pulmonary hypertension. Here we describe a molecular mechanism and animal model for this vascular pathology. Rodents engineered to express ...
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Keywords {🔍}
pulmonary, ang, lung, hypertension, cells, serotonin, muscle, cell, smooth, endothelial, animals, levels, human, vessels, adenoang, fig, tissue, treated, vascular, lungs, google, scholar, pubmed, doi, tie, protein, disease, gene, hpaec, arteriolar, pbs, artery, expression, injected, small, proliferation, animal, hypertensive, vessel, patients, adenolacz, rats, high, rodent, arterioles, pressures, medium, receptor, growth, results,
Topics {✒️}
carboxyl-terminal polyhistidine-epitope sequence independent [3h]thymidine/cell-count experiments muscle-specific growth factor diffuse small-vessel occlusion earlier dose–response experiments ang-1/tie2/serotonin paracrine pathway ang-1/tie2/serotonin feedback pathway serum-free media derived detectable steady-state levels liquid silicon-based polymer high steady-state levels endothelial-specific receptor tie2 pmc beta search ang-1-stimulated endothelial cells single membrane-bound transporter ang-1-treated endothelial cells ang-1-induced high levels ang-1-stimulated subcultured hpaec endothelial-derived serotonin acts ang-1-induced pulmonary hypertension small-vessel pathology persisted adeno-ang-1 showed staining anti-cd31 antibodies confirmed smooth muscle cells primary cell culturing rang-1-treated hpaec stimulated severe medial hyperplasia vector-specific ang-1 transcripts induces endothelial cells supplementary materials included growth factor specific ang-1/tie2/serotonin crosstalk viral-specific transcripts produced showed elevated levels ang-1-induced lung pathology cytoplasmic serotonin-specific staining growth factor secreted arteriolar vascular wall tie2 receptor phosphorylation pulmonary artery systolic anti-serotonin antibody shows repeat cellular experiments adeno-ang-1-treated lung pnas web site control adeno-lacz virus growth factor produced serum-free media advanced pulmonary hypertension ventricular septal defects human pulmonary artery
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