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We are analyzing https://www.nature.com/articles/nrm2009.

Title:
Notch signalling: a simple pathway becomes complex | Nature Reviews Molecular Cell Biology
Description:
The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation. A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
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30 years and 10 months (reg. 1994-08-11).

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Education
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🌆 Monumental Traffic: 20M - 50M visitors per month

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Keywords {🔍}

pubmed, google, scholar, cas, notch, cell, biol, development, signaling, drosophila, nature, central, dev, protein, proteins, delta, pathway, mol, complex, activity, activation, endocytosis, signalling, ubiquitin, regulation, curr, suppressor, transmembrane, cells, article, receptor, numb, ligand, access, domain, fringe, genes, required, hairless, cleavage, intracellular, ligands, promotes, regulates, elegans, chem, content, proteolytic, regulate, repression,

Topics {✒️}

nature portfolio permissions reprints medical research council privacy policy international cancer research advertising social media γ-secretase-mediated proteolysis author information authors nature cell biol phosphorylation-induced conformational change n-terminal amphipathic helix golgi-resident glycosyl-transferase nature rev mastermind recruits cycc–cdk8 author declares hairless-dependent molecular switch brm chromatin-remodeling complex post-golgi secretory vesicles ras-induced vulval development single-minded expressing cells human swi/snf brg1 c-terminal pdz-ligand nature genet snail–tom–neuralized pathway promotes ubiquitin-mediated turnover personal data g-protein-coupled receptors cell-specific gene activation ubiquitin-mediated protein degradation bearded-family members immature progenitor cells k-box-class micrornas endocytic protein α-adaptin γ-secretase complex data protection nature 435 nature 439 nature 426 nature 406 nature 420 nature springerlink instant access permissions molecular life sciences cell-surface-receptor signalling contact-dependent inhibition notch-signaling regulators numb nicd-transcription-activation complex γ-secretase activity

Questions {❓}

The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Why is Delta endocytosis required for effective activation of notch?

Schema {🗺️}

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