
NCBI . NLM . NIH . GOV {
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Title[redir]:
Evidence for Functional Redundancy Between C. elegans ADAM Proteins SUP-17/Kuzbanian and ADM-4/TACE - PMC
Description:
The ectodomain of LIN-12/Notch proteins is cleaved and shed upon ligand binding. In C. elegans, genetic evidence has implicated SUP-17, the ortholog of Drosophila Kuzbanian and mammalian ADAM10, as the protease that mediates this event. In mammals, ...
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Keywords {🔍}
doi, adm, lin, activity, elegans, pubmed, google, scholar, adam, glp, admok, tace, cell, phenotype, greenwald, cleavage, fig, phenotypes, mutants, notch, site, mutant, animals, double, pmc, scored, linnotch, defect, hermaphrodites, signaling, caenorhabditis, analysis, dev, cells, domain, family, sterility, redundant, article, genetic, fate, gonad, found, development, number, sterile, progeny, biol, functional, drosophila,
Topics {✒️}
pmc beta search soma-germ cell interactions mediate cell-cell interactions lin-12/notch mediated decisions adam10-deficient mice die a- egg-laying ability lin-12/notch proteins undergo temperature-shift experiments establish adm-4 double-stranded rna conserved metalloprotease-disintegrin protein cell-matrix interaction cell fate decisions facilitate lin-12/notch signaling alpha-secretase activity metalloprotease-disintegrin kuzbanian participates strong lin-12/notch phenotype notch pathway components cxc-chemokine ligand 16 caenorhabditis knockout consortium elegans lin-12/notch genes double-stranded rna rna-mediated interference highly penetrant defect reprolysin family includes display strong notch constitutively active receptor promotes germline mitosis human interleukin-6 receptor notch-pathway signaling wild-type parent zinc metalloprotease domain double mutant results glp-1-mediated signaling united states government pmc disclaimer license information pmcid proteolytic processing events c-terminal fragments phorbol ester stimulation qiagen rneasy columns transgenic lines protein weight matrix chi-square tests chi-square test epithelial adhesion protein sex myoblast migration vulval precursor cells elegans ko consortium reduced notch signaling bristol strain n2
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi