
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway - PMC
Description:
We have isolated mutations in the Drosophila melanogaster homologue of auxilin, a J-domain–containing protein known to cooperate with Hsc70 in the disassembly of clathrin coats from clathrin-coated vesicles in vitro. Consistent with this biochemical ...
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Keywords {🔍}
daux, notch, doi, pubmed, google, scholar, cell, cells, eye, fig, signaling, auxilin, mutant, endocytosis, clathrin, development, drosophila, discs, biol, function, embryos, pmc, internalization, role, ligand, domain, hsc, phenotype, wildtype, pathway, receptor, data, proteins, gmrgal, staining, clusters, delta, article, mutations, required, adult, photoreceptor, protein, suggests, expression, melanogaster, analysis, mutants, rough, bar,
Topics {✒️}
org/cgi/content/full/jcb springer-verlag berlin heidelberg pmc beta search tgf-beta homolog dpp van der bliek pmc copyright notice rat α-elav 7e8a10 full-length egf receptor 7-kb cooh-terminal portion supernumerary elav-positive cells daux w328x/daux i670k presumed force-generating event nearby wild-type cells multiple notch-dependent processes clc-gfp greatly reduced multiple boss-positive cells daux i670k/daux i670k wild-type eye discs normal elav-positive cells signal-sending cells promotes 9-kb ecori–spei fragment membrane-tethered intracellular domain cooh-terminal dnaj domain construct uas-daux-mrfp [doi] [pubmed] blaumueller nh2-terminal kinase domain ubiquitin-dependent endocytic pathway rab11-positive recycling endosomes phenotypically wild-type clusters construct uas-gfp-rab11 mouse α-dl c594 p-element–mediated transformation construct uas-dgrasp65-gfp online supplemental material elav-positive cells appeared dl-positive structures showed dsrna-mediated genetic interference rab7-positive vesicular structures proteasome-mediated protein degradation signal-competent notch fragment construct uas-dl-mrfp ubiquitin-mediated endocytic pathway excessive elav-positive cells elav-positive cell clusters cold spring harbor cargo-specific clathrin adaptor vesicular daux-mrfp appeared wild-type embryos injected delta-dependent intracellular processing gmr-gal4/daux i670k
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- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi