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pubmed, google, scholar, cas, notch, cell, biol, development, signaling, drosophila, nature, central, dev, protein, proteins, delta, pathway, mol, complex, activity, activation, endocytosis, signalling, ubiquitin, regulation, curr, suppressor, transmembrane, cells, article, receptor, numb, ligand, access, domain, fringe, genes, required, hairless, cleavage, intracellular, ligands, promotes, regulates, elegans, chem, content, proteolytic, regulate, repression,

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nature portfolio permissions reprints medical research council privacy policy international cancer research advertising social media γ-secretase-mediated proteolysis author information authors nature cell biol phosphorylation-induced conformational change n-terminal amphipathic helix golgi-resident glycosyl-transferase nature rev mastermind recruits cycc–cdk8 author declares hairless-dependent molecular switch brm chromatin-remodeling complex post-golgi secretory vesicles ras-induced vulval development single-minded expressing cells human swi/snf brg1 c-terminal pdz-ligand nature genet snail–tom–neuralized pathway promotes ubiquitin-mediated turnover personal data g-protein-coupled receptors cell-specific gene activation ubiquitin-mediated protein degradation bearded-family members immature progenitor cells k-box-class micrornas endocytic protein α-adaptin γ-secretase complex data protection nature 435 nature 439 nature 426 nature 406 nature 420 nature springerlink instant access permissions molecular life sciences cell-surface-receptor signalling contact-dependent inhibition notch-signaling regulators numb nicd-transcription-activation complex γ-secretase activity

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• The role of Notch in tumorigenesis: oncogene or tumour suppressor?
• Why is Delta endocytosis required for effective activation of notch?

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