NATURE . COM {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Nature.com Make Money
How Much Does Nature.com Make
Keywords
Topics
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We are analyzing https://www.nature.com/articles/nrm2009.

Title:
Notch signalling: a simple pathway becomes complex | Nature Reviews Molecular Cell Biology
Description:
The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation. A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)

google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)

conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

pubmed, google, scholar, cas, notch, cell, biol, development, signaling, drosophila, nature, central, dev, protein, proteins, delta, pathway, mol, complex, activity, activation, endocytosis, signalling, ubiquitin, article, regulation, curr, suppressor, transmembrane, cells, receptor, numb, ligand, access, domain, fringe, genes, required, hairless, cleavage, intracellular, links, ligands, promotes, regulates, elegans, chem, content, proteolytic, regulate,

Topics {✒️}

nature portfolio permissions reprints medical research council privacy policy international cancer research advertising author information authors social media γ-secretase-mediated proteolysis nature cell biol author declares phosphorylation-induced conformational change n-terminal amphipathic helix golgi-resident glycosyl-transferase nature rev mastermind recruits cycc–cdk8 hairless-dependent molecular switch brm chromatin-remodeling complex post-golgi secretory vesicles ras-induced vulval development single-minded expressing cells human swi/snf brg1 c-terminal pdz-ligand nature genet snail–tom–neuralized pathway promotes ubiquitin-mediated turnover personal data g-protein-coupled receptors cell-specific gene activation ubiquitin-mediated protein degradation bearded-family members immature progenitor cells k-box-class micrornas endocytic protein α-adaptin γ-secretase complex data protection nature 435 nature 439 nature 426 nature 406 nature 420 nature springerlink instant access key proteins molecular life sciences cell-surface-receptor signalling contact-dependent inhibition notch-signaling regulators numb nicd-transcription-activation complex γ-secretase activity

Questions {❓}

The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Why is Delta endocytosis required for effective activation of notch?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Notch signalling: a simple pathway becomes complex
         description: The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation. A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
         datePublished:
         dateModified:
         pageStart:678
         pageEnd:689
         sameAs:https://doi.org/10.1038/nrm2009
         keywords:
            Life Sciences
            general
            Cell Biology
            Cancer Research
            Developmental Biology
            Stem Cells
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Figb_HTML.jpg
         isPartOf:
            name:Nature Reviews Molecular Cell Biology
            issn:
               1471-0080
               1471-0072
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Sarah J. Bray
               affiliation:
                     name:Development and Neuroscience, University of Cambridge
                     address:
                        name:Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Notch signalling: a simple pathway becomes complex
      description: The Notch pathway functions during diverse developmental and physiological processes. Our current understanding of the mechanisms that function on the core Notch pathway shows that we are still just beginning to understand the full complexities of Notch regulation. A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
      datePublished:
      dateModified:
      pageStart:678
      pageEnd:689
      sameAs:https://doi.org/10.1038/nrm2009
      keywords:
         Life Sciences
         general
         Cell Biology
         Cancer Research
         Developmental Biology
         Stem Cells
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrm2009/MediaObjects/41580_2006_Article_BFnrm2009_Figb_HTML.jpg
      isPartOf:
         name:Nature Reviews Molecular Cell Biology
         issn:
            1471-0080
            1471-0072
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sarah J. Bray
            affiliation:
                  name:Development and Neuroscience, University of Cambridge
                  address:
                     name:Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Molecular Cell Biology
      issn:
         1471-0080
         1471-0072
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Development and Neuroscience, University of Cambridge
      address:
         name:Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sarah J. Bray
      affiliation:
            name:Development and Neuroscience, University of Cambridge
            address:
               name:Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(316)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mxa-002c5801.gslb.pphosted.com
mxb-002c5801.gslb.pphosted.com

Name Servers:

pdns1.ultradns.net
pdns2.ultradns.net
pdns3.ultradns.org
pdns4.ultradns.org
pdns5.ultradns.info
pdns6.ultradns.co.uk

CDN Services {📦}

Crossref

4.68s.