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We are analyzing https://www.nature.com/articles/nri.2017.125.

Title:
Microglia and macrophages in brain homeostasis and disease | Nature Reviews Immunology
Description:
This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases. Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, molecular and pharmacological tools, considerable advances have been made towards our understanding of the embryonic origins, developmental programmes and functions of these cells. These exciting discoveries, some of which are still controversial, also raise many new questions, which makes brain macrophage biology a fast-growing field at the intersection of neuroscience and immunology. Here, we review the current knowledge of how and where brain macrophages are generated, with a focus on parenchymal microglia. We also discuss their normal functions during development and homeostasis, the disturbance of which may lead to various neurodegenerative and neuropsychiatric diseases.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Business & Finance

Content Management System {πŸ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of nature.com audience?

πŸŒ† Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

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How Does Nature.com Make Money? {πŸ’Έ}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {πŸ’°}


Display Ads {🎯}

$531,700 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $354,480 to $974,820.

Keywords {πŸ”}

pubmed, google, scholar, cas, central, microglia, nat, microglial, neurosci, nature, brain, cell, cells, macrophages, disease, development, system, alzheimers, immunol, function, neuron, article, science, stem, homeostasis, cns, tissueresident, access, adult, mouse, macrophage, human, immunity, rev, mice, trem, nervous, developmental, fate, monocytes, complement, receptor, myeloid, model, content, barres, functional, embryonic, postnatal, molecular,

Topics {βœ’οΈ}

permissions reprints nature portfolio journals yolk-sac-derived erythro-myeloid progenitors privacy policy nature portfolio selective regional sensitivities author information authors advertising multi-centre case-control study single-cell rna-seq analyses unique tgf-Ξ²-dependent molecular social media editing genome-wide transcriptional profiling stroma-derived interleukin-34 controls neurodegeneration-specific gene-expression signature virus-induced memory impairment lineage-specific transcription factor cx3cr1/p38 mapk pathway prominent white-matter structure ipsc-derived human microglia ipsc-derived human microglia injured blood-brain barrier erythro-myeloid progenitors cell-mediated immune mechanisms unknown brain-derived signals maintain region-specific phenotypes precise nature pharmacological tools antigen–antibody immune complexes culture-specific expression profile nerve injury-induced cleavage personal data blood-brain barrier integrity neuron-restricted cytomegalovirus latency central nervous system vivo single-cell imaging tissue-resident macrophages originate transcription factor runx1 nature+ nature nature 518 nature 468 nature 497 nature 534 nature 530 nature 504 nature 532 nature 438 nature 505

Questions {❓}

  • A polarizing question: do M1 and M2 microglia exist?
  • Does niche competition determine the origin of tissue-resident macrophages?
  • Microglia: scapegoat, saboteur, or something else?

Schema {πŸ—ΊοΈ}

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      description: This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases. Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, molecular and pharmacological tools, considerable advances have been made towards our understanding of the embryonic origins, developmental programmes and functions of these cells. These exciting discoveries, some of which are still controversial, also raise many new questions, which makes brain macrophage biology a fast-growing field at the intersection of neuroscience and immunology. Here, we review the current knowledge of how and where brain macrophages are generated, with a focus on parenchymal microglia. We also discuss their normal functions during development and homeostasis, the disturbance of which may lead to various neurodegenerative and neuropsychiatric diseases.
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