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Keywords {🔍}

microglia, tmem, doi, cells, fig, pubmed, google, scholar, expression, appendix, microglial, brain, genes, pmc, article, cns, highly, free, cell, expressed, macrophages, mouse, injury, gene, human, rnaseq, myeloid, development, adult, iba, marker, disease, antibodies, mice, data, table, function, activation, profiles, compared, tissue, protein, nerve, specific, bars, isolation, analysis, peripheral, health, studies,

Topics {✒️}

vitamin d3-receptor/rxr activation unique tgf-β-dependent molecular org/web/packages/pvclust/index genome-wide rna-seq analysis neurodegeneration-specific gene-expression signature indomethacin-induced gastric ulceration astrocyte-secreted proteins hevin hypoxanthine-guanine phosphoribosyltransferase deficiency classic-type activation profile debris-filled crush site pmc beta search custom monoclonal antibodies—correlates full cufflinks-generated fragments brain-derived neurotrophic factor dissecting microglia-specific contributions tmem119-driven gene expression low-level synaptic contamination org/lookup/suppl/doi blood-brain barrier integrity lipopolysaccharide-induced microglial activation activation-induced microglial proliferation cell-type–specific markers cell-type–specific genes microglia-enriched genes demonstrated health research fellowship cell-cycle gene expression top lps-induced genes developed microglia-specific antibodies injured blood-brain barrier supplementary materials included complement-dependent manner schematic showing timing pdgf-b-deficient mice supplementary file pnas ko lacking cx3cr1-gfp developed monoclonal antibodies pathway analysis revealed anti-mouse mabs optic nerve crush rat optic nerve anti-iba1 antibodies proliferating tmem119+iba1+ cells stanford tissue bank macrophage abstract nucleic acids res induce platelet aggregation anti-tmem119 antibodies user-friendly website cell-type–specific highly express trem2

Questions {❓}

• Are the signals regulating developmental and activation-induced microglial proliferation different?
• Could microglia contribute to hemostatic functions in the CNS?
• Finally, what does Tmem119 do?
• Microglia: Scapegoat, saboteur, or something else?
• These observations raise an important question for future studies: what signals induce microglial maturation?
• What does its regulation during development mean for microglial function?
• What is the relationship of microglial proliferation to maturity, and then to activation?

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• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
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