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Topics {✒️}

scientific research permissions reprints privacy policy nature portfolio β-catenin–tcf-4 complex imposes western-style high-risk diet normal apc–β-catenin signaling advertising p21waf1/cip1/sdi1 prevents apoptosis antigen-induced t-cell proliferation tumour suppressor p21waf1/cip1/sdi1 social media cyclin d1-imposed block key tumour-suppressor pathways ej c-ha-ras oncogene author information authors cyclin d-dependent kinases g1 cyclin-dependent kinases stress-activated protein kinases inhibit cyclin-dependent kinases netherlands cancer institute author correspondence zinc-finger protein expressed sharing unpublished data cdk-inhibitor p21cip1/waf1 inducing p21waf1/cip1 expression bypassing ras-induced senescence tgf-β cytoinhibitory effect sm α-actin expression p21waf1/cip1-deficient mice early-stage breast cancer keratinocyte stem-cell potential context-dependent opposing forces inducing cell-cycle arrest senescent cell-derived inhibitors cyclin-dependent kinase 4 cytoplasmic p21waf1/cip1 expression candidate anti-cancer barrier c-myc trans-activates serine threonine kinase springerlink instant access nature cell biol dna damage-induced apoptosis skin tumor development permissions erk-mediated bim suppression tgfβ-induced growth inhibition p21waf1/cip1 mediates tgf-β–smad colon cancer cells

Questions {❓}

• Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
• Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
• The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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