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Title[redir]:
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation - PMC
Description:
The role of Notch signaling in growth/differentiation control of mammalian epithelial cells is still poorly defined. We show that keratinocyte-specific deletion of the Notch1 gene results in marked epidermal hyperplasia and deregulated expression of ...
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Keywords {🔍}
notch, expression, promoter, keratinocytes, differentiation, activated, activity, rbpjκ, figure, induced, cells, induction, doi, cell, involucrin, pubmed, google, scholar, markers, control, gene, mouse, calcium, region, similar, binding, keratinocyte, growth, antibodies, protein, conditions, early, epidermis, transfected, domain, transcription, mice, keratin, hesab, vector, pmc, deletion, proteins, increased, endogenous, marker, primary, signaling, ank, independent,
Topics {✒️}
abrogate rbp-jκ/notch-dependent transcription temporally-controlled site-specific mutagenesis dominant-negative rbp-jκ mutant rbp-jκ dominant-negative mutant induce rbp-jκ-dependent transcription notch/rbp-jκ-responsive region dna-binding protein rbp-jκ notch-responsive hes-ab promoter p21waf1/cip1-dependent mechanism epstein–barr virus ebna2 epstein–barr virus immortalization dominant-negative rbp-jκ rbp-jκ mutant protein full-length involucrin promoter rbp-jκ binding site rbp-jκ-dependent transcription rbp-jκ-dependent mechanism rbp-jκ binding sites anti-sense notch1 cdna nf-κb p65 expression mouse cbf1/rbp-jκ pmc beta search texas red-conjugated streptavidin promotes ras-tumor progression nf-κb-dependent transcription mouse p21waf1/cip1 promoter inducing p21waf1/cip1 expression massachusetts general hospital/shiseido sp1/sp3 binding sites serrate/jagged families play cytoplasmic sh3-binding protein adjacent hair-shaft layers anti-rbp-jκ antibodies p21waf1/cip1 protein expression nf-κb-responsive promoters mutated hes-δab promoter rbp-jκ-independent mechanism anti-sense notch1 expression mouse c-jun promoter rbp-jκ binding sequence nuclear factor-κb proteins rbp-jκ-dependent induction tamoxifen-inducible cre-er vivo formaldehyde cross-linking supra-basal epidermal layers ad-notch1 adenovirus versus c-jun mouse gene ras-gtpase activating protein keratinocyte-specific conditional deletion inducible keratinocyte-specific deletion
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