Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nrc1780.

Title:
KLF4, p21 and context-dependent opposing forces in cancer | Nature Reviews Cancer
Description:
Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer. Krüppel-like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell-cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

pubmed, google, scholar, cas, cancer, cell, factor, nature, kruppellike, central, klf, gene, biol, cells, oncogene, growth, expression, res, tumor, human, suppressor, transcription, chem, mice, gutenriched, factors, loss, pwafcip, genes, transcriptional, sci, yang, protein, proc, natl, acad, usa, differentiation, breast, inhibitor, transforming, apoptosis, mol, genet, family, article, functions, kinase, access, tgfβ,

Topics {✒️}

scientific research permissions reprints privacy policy nature portfolio β-catenin–tcf-4 complex imposes western-style high-risk diet normal apc–β-catenin signaling advertising p21waf1/cip1/sdi1 prevents apoptosis antigen-induced t-cell proliferation tumour suppressor p21waf1/cip1/sdi1 social media cyclin d1-imposed block key tumour-suppressor pathways ej c-ha-ras oncogene author information authors cyclin d-dependent kinases g1 cyclin-dependent kinases stress-activated protein kinases inhibit cyclin-dependent kinases netherlands cancer institute author correspondence zinc-finger protein expressed sharing unpublished data cdk-inhibitor p21cip1/waf1 inducing p21waf1/cip1 expression bypassing ras-induced senescence tgf-β cytoinhibitory effect sm α-actin expression p21waf1/cip1-deficient mice early-stage breast cancer keratinocyte stem-cell potential context-dependent opposing forces inducing cell-cycle arrest senescent cell-derived inhibitors cyclin-dependent kinase 4 cytoplasmic p21waf1/cip1 expression candidate anti-cancer barrier c-myc trans-activates serine threonine kinase springerlink instant access nature cell biol dna damage-induced apoptosis skin tumor development permissions erk-mediated bim suppression tgfβ-induced growth inhibition p21waf1/cip1 mediates tgf-β–smad colon cancer cells

Questions {❓}

  • Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
  • Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
  • The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:KLF4, p21 and context-dependent opposing forces in cancer
         description:Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer. Krüppel-like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell-cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
         datePublished:2005-12-22T00:00:00Z
         dateModified:2005-12-22T00:00:00Z
         pageStart:11
         pageEnd:23
         sameAs:https://doi.org/10.1038/nrc1780
         keywords:
            Biomedicine
            general
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig6_HTML.jpg
         isPartOf:
            name:Nature Reviews Cancer
            issn:
               1474-1768
               1474-175X
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Benjamin D. Rowland
               affiliation:
                     name:The Netherlands Cancer Institute, Plesmanlaan 121
                     address:
                        name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel S. Peeper
               affiliation:
                     name:The Netherlands Cancer Institute, Plesmanlaan 121
                     address:
                        name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:KLF4, p21 and context-dependent opposing forces in cancer
      description:Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer. Krüppel-like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell-cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
      datePublished:2005-12-22T00:00:00Z
      dateModified:2005-12-22T00:00:00Z
      pageStart:11
      pageEnd:23
      sameAs:https://doi.org/10.1038/nrc1780
      keywords:
         Biomedicine
         general
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrc1780/MediaObjects/41568_2006_Article_BFnrc1780_Fig6_HTML.jpg
      isPartOf:
         name:Nature Reviews Cancer
         issn:
            1474-1768
            1474-175X
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Benjamin D. Rowland
            affiliation:
                  name:The Netherlands Cancer Institute, Plesmanlaan 121
                  address:
                     name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel S. Peeper
            affiliation:
                  name:The Netherlands Cancer Institute, Plesmanlaan 121
                  address:
                     name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Cancer
      issn:
         1474-1768
         1474-175X
      volumeNumber:6
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Netherlands Cancer Institute, Plesmanlaan 121
      address:
         name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
         type:PostalAddress
      name:The Netherlands Cancer Institute, Plesmanlaan 121
      address:
         name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Benjamin D. Rowland
      affiliation:
            name:The Netherlands Cancer Institute, Plesmanlaan 121
            address:
               name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Daniel S. Peeper
      affiliation:
            name:The Netherlands Cancer Institute, Plesmanlaan 121
            address:
               name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
      name:Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(476)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.02s.