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We are analyzing https://www.nature.com/articles/nrc1780.

Title:
KLF4, p21 and context-dependent opposing forces in cancer | Nature Reviews Cancer
Description:
Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer. Krüppel-like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell-cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
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Keywords {🔍}

pubmed, google, scholar, cas, cancer, cell, factor, nature, kruppellike, central, klf, gene, biol, cells, oncogene, growth, expression, res, tumor, human, suppressor, transcription, chem, mice, gutenriched, factors, loss, pwafcip, genes, transcriptional, sci, yang, protein, proc, natl, acad, usa, differentiation, breast, inhibitor, transforming, apoptosis, mol, genet, family, article, functions, kinase, access, tgfβ,

Topics {✒️}

scientific research permissions reprints privacy policy nature portfolio β-catenin–tcf-4 complex imposes western-style high-risk diet normal apc–β-catenin signaling advertising p21waf1/cip1/sdi1 prevents apoptosis antigen-induced t-cell proliferation tumour suppressor p21waf1/cip1/sdi1 social media cyclin d1-imposed block key tumour-suppressor pathways ej c-ha-ras oncogene author information authors cyclin d-dependent kinases g1 cyclin-dependent kinases stress-activated protein kinases inhibit cyclin-dependent kinases netherlands cancer institute author correspondence zinc-finger protein expressed sharing unpublished data cdk-inhibitor p21cip1/waf1 inducing p21waf1/cip1 expression bypassing ras-induced senescence tgf-β cytoinhibitory effect sm α-actin expression p21waf1/cip1-deficient mice early-stage breast cancer keratinocyte stem-cell potential context-dependent opposing forces inducing cell-cycle arrest senescent cell-derived inhibitors cyclin-dependent kinase 4 cytoplasmic p21waf1/cip1 expression candidate anti-cancer barrier c-myc trans-activates serine threonine kinase springerlink instant access nature cell biol dna damage-induced apoptosis skin tumor development permissions erk-mediated bim suppression tgfβ-induced growth inhibition p21waf1/cip1 mediates tgf-β–smad colon cancer cells

Questions {❓}

  • Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?
  • Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
  • The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Schema {🗺️}

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