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Epigenetic choreographers of neurogenesis in the adult mammalian brain | Nature Neuroscience
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This review examines evidence supporting diverse roles for epigenetic mechanisms in regulating specific aspects of adult neurogenesis and their implications. Epigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can lead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
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nature portfolio permissions reprints privacy policy advanced research high-resolution genome-wide mapping advertising research social media guo-li ming & hongjun song author information authors activity-dependent extrinsic regulation long-lasting biological effects nature 466 nature 462 nature 425 nature 458 nature 450 nature 460 nature 435 nature 441 nature author correspondence polycomb/trithorax response elements personal data early-life adverse experiences smrt-mediated repression activity-dependent suppression genome-wide mapping data protection review recent evidence springerlink instant access permissions genome integrates intrinsic article ma mecp2 deficiency leads regulate synaptic function guo-li ming neural stem cell neural precursor cells quantitating neural stem active dna demethylation calcium-dependent switch human dna methylomes brain-specific phosphorylation adult olfactory bulb regulating specific aspects genetic variant bdnf embryonic stem cells maria carolina marchetto �color timer” mice
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