
NCBI . NLM . NIH . GOV {
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Title[redir]:
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis - PMC
Description:
In adult hippocampus, new neurons are continuously generated from neural stem cells (NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive. We found that Wnt signaling, together with the removal of Sox2, triggered the ...
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Keywords {🔍}
cells, neurod, sox, adult, doi, fig, line, βcatenin, mice, neuronal, expression, promoter, nscs, control, pubmed, google, scholar, wnt, neurogenesis, neurons, gyrus, wnta, dentate, cell, activation, signaling, luciferase, gene, cko, supplementary, sites, activity, genes, pmc, regulatory, soxlef, differentiation, analysis, hippocampus, mouse, neurodpositive, development, antibody, article, gfp, sequences, lentivirus, transcription, rat, results,
Topics {✒️}
aac aaa proneural basic helix-loop-helix wnt/β-catenin–mediated neuronal differentiation β-catenin–expressing lentiviral vectors wnt/β-catenin signaling represents noncanonical37 wnt/β-catenin signaling canonical wnt/β-catenin pathway canonical wnt/β-catenin signaling wnt/β-catenin-mediated activation sox/lef-binding sites act neurod1-positive progenitor cells/neuroblasts canonical wnt/β-catenin activation wnt1-cre–mediated deletion results sox/lef-binding sites upstream stem/progenitor cell pool shrna-gfp–positive cells colocalized wnt-mediated regulatory mechanism astrocyte-derived wnt signals minimal promoter-driven luciferase protein-protein interactions facilitated wwc aaa hiv-based lentiviral vector wnt/β-catenin signaling detected line-gfp–positive cells di-methylated histone h3 e-protein binding sites β-catenin conditional knockout β-catenin cko mice cre-gfp fusion protein rat β-catenin transcript wnt-mediated transcriptional activation wnt/β-catenin activation hippocampal astrocyte–derived factors pmc beta search neurod1 promoter–driven luciferase β-catenin activator complex turbo dna-free sox/lef regulatory sites sox/lef regulatory elements traced gfp-positive cells wnt3a-mediated neuronal differentiation sox/lef-binding site sox/lef binding sequence sox/lef-binding sites gfp double-positive cells wnt3a-mediated induced production gfp-positive cells colocalized quantitative real-time pcr real-time pcr machine loxp-flanked stop codon
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- Foundation
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi