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We are analyzing https://www.nature.com/articles/ni.3118.

Title:
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection | Nature Immunology
Description:
The mechanisms that control activation of the AIM2 inflammasome by cytosolic bacteria are unclear. Kanneganti and colleagues demonstrate that a pathway involving the transcription factor IRF1 is required for the activation of AIM2. Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear. Here we found that the transcription factor IRF1 was required for activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida), whereas engagement of the AIM2 inflammasome by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require IRF1. Infection of F. novicida detected by the DNA sensor cGAS and its adaptor STING induced type I interferon–dependent expression of IRF1, which drove the expression of guanylate-binding proteins (GBPs); this led to intracellular killing of bacteria and DNA release. Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

pubmed, article, google, scholar, cas, nature, inflammasome, novicida, activation, central, irf, aim, bmdms, caspase, infected, infection, moi, dna, cell, research, francisella, access, gene, supplementary, expression, nat, immunity, unprimed, content, proteins, type, immunol, innate, independent, experiments, gbp, essential, data, immunology, guanylatebinding, tularensis, disease, science, induction, cookies, factor, intracellular, usa, role, bacterial,

Topics {✒️}

scientific research-flanders nature portfolio permissions reprints privacy policy aberrant lymphocyte development advertising social media medical protein research medical research council author information authors relevant small-molecule compounds thirumala-devi kanneganti european research council recombinant mouse ifn-β real time qrt-pcr author correspondence functional cross-species conservation interferon-dependent immune responses adaptor inducing interferon-β heinrich-heine-university duesseldorf interferon-dependent innate immunity ifn-induced gtpases springerlink instant access nature 481 nature 458 nature 490 nature 474 nature 479 nature 509 nature 514 nature 408 nature 461 nature 434 nature 440 nature 430 nature research hospital transfected double-stranded dna pro-inflammatory cytokines permissions massachusetts medical school tlr4-independent endotoxic shock innate immune recognition article man american lebanese syrian mounting host defense human pyhin proteins relative gene expression guanylate-binding proteins mouse strain distribution

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