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Title:
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells | Nature Immunology
Description:
The transcription factor BATF is known to control switched antibody responses. Murphy and colleagues show that BATF functions at multiple hierarchical levels in follicular helper T cells and B cells to regulate these responses. The transcription factor BATF controls the differentiation of interleukin 17 (IL-17)-producing helper T cells (TH17 cells) by regulating expression of the transcription factor RORγt itself and RORγt target genes such as Il17. Here we report the mechanism by which BATF controls in vivo class-switch recombination (CSR). In T cells, BATF directly controlled expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of follicular helper T cells (TFH cells). Restoring TFH cell activity to Batf−/− T cells in vivo required coexpression of Bcl-6 and c-Maf. In B cells, BATF directly controlled the expression of both activation-induced cytidine deaminase (AID) and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (IH-CH). Thus, BATF functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo.
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nature portfolio permissions reprints privacy policy research advertising social media intervening heavy-chain region constant heavy-chain region germinal center-derived memory author information authors activation-induced cytidine deaminase nature 460 nature 455 nature 429 nature 422 nature 448 nature transcription-targeted dna deamination exposing single-stranded dna vivo class-switch recombination author correspondence stat5 promotes accessibility batf3 deficiency reveals retroviruses bcl-6-gfp rv personal data central memory cd4+ class-switch recombination class switch recombination springerlink instant access gata-3-dependent enhancer activity data protection permissions cytolytic effector cd8+ transcription factor rorγt ap-1 mediated transcription s-region transcription ifn-γ reporters il-4 gene regulation lymphocyte attenuator regulates harvard medical school irf4 transcription factors class-switch assays transcription factors bcl-6 batf directly controlled additional factors regulate activator protein-1 activity privacy vivo antibody responses immune disease institute dysregulated immune responses
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