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Title[redir]:
Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors - PMC
Description:
Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. We identified an IL-21 response element downstream of ...
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Keywords {π}
irf, stat, cells, prdm, expression, figure, doi, sites, binding, cell, gene, ilinduced, genes, pubmed, google, scholar, ngml, response, treatment, mice, shown, table, element, activity, experiments, motif, independent, site, chipseq, data, blimp, differentiation, region, control, irfbinding, pmc, combined, motifs, total, splenic, preactivated, means, sem, samples, luciferase, suppl, article, mrna, nihmssupplementsuppltablexls, xls,
Topics {βοΈ}
supplementary document nihms352341-supplement-supplementary_document transcription-factor-binding prediction software stat3f/f-cd19-cre+/β mice il-21-treated stat3f/f-creβ/β cells genome-wide chip-seq mapping 3 Β΅g/ml anti-igm-fab stat3f/f-cd19-cre+/β rel/nuclear factor kappab pmc beta search chi-square analysis revealed processing chip-seq data table 2 nihms352341-supplement-suppl__table_2 table 3 nihms352341-supplement-suppl__table_3 table 4 nihms352341-supplement-suppl__table_4 table 5 nihms352341-supplement-suppl__table_5 table 6 nihms352341-supplement-suppl__table_6 table 7 nihms352341-supplement-suppl__table_7 table 8 nihms352341-supplement-suppl__table_8 table 9 nihms352341-supplement-suppl__table_9 mediate il-21-induced regulation stat3f/f-creβ/+ mice pna+b220+ germinal center il-21-induced pim1 expression sfpi1f/f-cd19-cre+/β exhibited il-21-induced activity il-21-induced prdm1 expression chip-seq tag density supplementary material suppl comprehensive cdna-supported gene il-21-induced luciferase activity lymphocyte-restricted transcription factor putative irf-binding motif interferon-regulated gene expression plate-bound anti-cd3Ξ΅ lps-induced prdm1 induction found il-21-induced complexes il-21-induced blimp1 expression eliminated il-21-induced activity irf4 chip-seq tags irf4-chip-seq tags 1 Β΅g/ml anti-cd40 il-21-induced follicular helper knowing binding-site locations stat3 chip-seq tags 50 ng/ml ifn-Ξ³ interferon regulatory factor-4 interferon regulatory factor il-21-induced socs3 expression il-21-induced stat3 binding lymphocyte-induced maturation protein-1
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