NATURE . COM {}

Matching Content Categories {📚}

• Science
• Health & Fitness
• Education

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

article, google, scholar, cas, nature, arthritis, sakaguchi, cells, supplementary, cell, autoimmune, selection, access, zap, mice, receptor, content, tcell, disease, thymus, immunol, science, research, japan, figure, cookies, rheumatoid, development, ads, jpg, privacy, thymic, mutation, tcr, fig, data, information, journal, gene, noriko, takahashi, shimon, chronic, systemic, diseases, med, zeta, authors, author, essential,

Topics {✒️}

nature portfolio permissions reprints privacy policy riken research center advertising social media normal t-cell development subscribe nature nature med nature immunol research nature 376 nature 333 nature 335 nature 426 nature graft-versus-host reaction ankylosing spondylitis treatment 70 kd protein-tyrosine kinase t-cell antigen receptor organ-specific disease provoked itim motif-carrying immunoreceptor reactive t-cell clones map-kinase signaling pathway author correspondence personal data cd4+cd8+tcrlo thymocytes arrests thymocyte development springerlink instant access t-cell repertoire data protection permissions altered signal transduction mice noriko sakaguchi t-cell selection direct cell contact tcr zeta chain zap-70-deficient mice specific itam phosphorylations thymic selection revisited chronic autoimmune arthritis privacy alternative antigen receptor rheumatoid arthritis chronic progressive polyarthritis competing financial interests cell signalling abnormalities rheumatology 5th edn adjuvant-induced model explore content

Questions {❓}

• Thymic selection revisited: how essential is it?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
         description:Rheumatoid arthritis (RA), which afflicts about 1% of the world population, is a chronic systemic inflammatory disease of unknown aetiology that primarily affects the synovial membranes of multiple joints1,2,3. Although CD4+ T cells seem to be the prime mediators of RA, it remains unclear how arthritogenic CD4+ T cells are generated and activated1,2,3. Given that highly self-reactive T-cell clones are deleted during normal T-cell development in the thymus, abnormality in T-cell selection has been suspected as one cause of autoimmune disease4,5. Here we show that a spontaneous point mutation of the gene encoding an SH2 domain of ZAP-70, a key signal transduction molecule in T cells6, causes chronic autoimmune arthritis in mice that resembles human RA in many aspects. Altered signal transduction from T-cell antigen receptor through the aberrant ZAP-70 changes the thresholds of T cells to thymic selection, leading to the positive selection of otherwise negatively selected autoimmune T cells. Thymic production of arthritogenic T cells due to a genetically determined selection shift of the T-cell repertoire towards high self-reactivity might also be crucial to the development of disease in a subset of patients with RA.
         datePublished:
         dateModified:
         pageStart:454
         pageEnd:460
         sameAs:https://doi.org/10.1038/nature02119
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:426
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Noriko Sakaguchi
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
                     name:RIKEN Research Center for Allergy and Immunology
                     address:
                        name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takeshi Takahashi
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hiroshi Hata
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takashi Nomura
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tomoyuki Tagami
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sayuri Yamazaki
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Toshiko Sakihama
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takaji Matsutani
               affiliation:
                     name:Shionogi Institute for Medical Science
                     address:
                        name:Department of Immunology, Shionogi Institute for Medical Science, Settsu, Osaka, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Izumi Negishi
               affiliation:
                     name:Gunma University Hospital
                     address:
                        name:Department of Dermatology, Gunma University Hospital, Maebashi, Gunma, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Syuichi Nakatsuru
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shimon Sakaguchi
               affiliation:
                     name:Kyoto University
                     address:
                        name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
                     name:RIKEN Research Center for Allergy and Immunology
                     address:
                        name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
      description:Rheumatoid arthritis (RA), which afflicts about 1% of the world population, is a chronic systemic inflammatory disease of unknown aetiology that primarily affects the synovial membranes of multiple joints1,2,3. Although CD4+ T cells seem to be the prime mediators of RA, it remains unclear how arthritogenic CD4+ T cells are generated and activated1,2,3. Given that highly self-reactive T-cell clones are deleted during normal T-cell development in the thymus, abnormality in T-cell selection has been suspected as one cause of autoimmune disease4,5. Here we show that a spontaneous point mutation of the gene encoding an SH2 domain of ZAP-70, a key signal transduction molecule in T cells6, causes chronic autoimmune arthritis in mice that resembles human RA in many aspects. Altered signal transduction from T-cell antigen receptor through the aberrant ZAP-70 changes the thresholds of T cells to thymic selection, leading to the positive selection of otherwise negatively selected autoimmune T cells. Thymic production of arthritogenic T cells due to a genetically determined selection shift of the T-cell repertoire towards high self-reactivity might also be crucial to the development of disease in a subset of patients with RA.
      datePublished:
      dateModified:
      pageStart:454
      pageEnd:460
      sameAs:https://doi.org/10.1038/nature02119
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_Article_BFnature02119_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:426
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Noriko Sakaguchi
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
                  name:RIKEN Research Center for Allergy and Immunology
                  address:
                     name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takeshi Takahashi
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroshi Hata
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takashi Nomura
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tomoyuki Tagami
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sayuri Yamazaki
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Toshiko Sakihama
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takaji Matsutani
            affiliation:
                  name:Shionogi Institute for Medical Science
                  address:
                     name:Department of Immunology, Shionogi Institute for Medical Science, Settsu, Osaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Izumi Negishi
            affiliation:
                  name:Gunma University Hospital
                  address:
                     name:Department of Dermatology, Gunma University Hospital, Maebashi, Gunma, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Syuichi Nakatsuru
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shimon Sakaguchi
            affiliation:
                  name:Kyoto University
                  address:
                     name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
                  name:RIKEN Research Center for Allergy and Immunology
                  address:
                     name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:426
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:RIKEN Research Center for Allergy and Immunology
      address:
         name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Shionogi Institute for Medical Science
      address:
         name:Department of Immunology, Shionogi Institute for Medical Science, Settsu, Osaka, Japan
         type:PostalAddress
      name:Gunma University Hospital
      address:
         name:Department of Dermatology, Gunma University Hospital, Maebashi, Gunma, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:Kyoto University
      address:
         name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
         type:PostalAddress
      name:RIKEN Research Center for Allergy and Immunology
      address:
         name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Noriko Sakaguchi
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
            name:RIKEN Research Center for Allergy and Immunology
            address:
               name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
               type:PostalAddress
            type:Organization
      name:Takeshi Takahashi
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Hiroshi Hata
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Takashi Nomura
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Tomoyuki Tagami
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Sayuri Yamazaki
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Toshiko Sakihama
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Takaji Matsutani
      affiliation:
            name:Shionogi Institute for Medical Science
            address:
               name:Department of Immunology, Shionogi Institute for Medical Science, Settsu, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Izumi Negishi
      affiliation:
            name:Gunma University Hospital
            address:
               name:Department of Dermatology, Gunma University Hospital, Maebashi, Gunma, Japan
               type:PostalAddress
            type:Organization
      name:Syuichi Nakatsuru
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Shimon Sakaguchi
      affiliation:
            name:Kyoto University
            address:
               name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
               type:PostalAddress
            type:Organization
            name:RIKEN Research Center for Allergy and Immunology
            address:
               name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Immunology, Shionogi Institute for Medical Science, Settsu, Osaka, Japan
      name:Department of Dermatology, Gunma University Hospital, Maebashi, Gunma, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
      name:Laboratory for Immunopathology, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(105)

• Get to know https://link.springer.com/article/10.1038/nature02119?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle's earnings
• How much does http://scholar.google.com/scholar_lookup?&title=Rheumatoid%20Arthritis&publication_year=1997&author=Harris%2CED pull in monthly?
• How much income is https://doi.org/10.1016%2FS0092-8674%2800%2981109-5 earning monthly?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Rheumatoid%20arthritis&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981109-5&volume=85&pages=307-310&publication_year=1996&author=Feldmann%2CM&author=Brennan%2CFM&author=Maini%2CRN
• How much does http://scholar.google.com/scholar_lookup?&title=Textbook%20of%20Rheumatology&pages=851-897&publication_year=1997&author=Firestein%2CGF earn?
• https://doi.org/10.1038%2F90935's revenue stream
• How profitable is http://scholar.google.com/scholar_lookup?&title=Autoimmune%20disease%3A%20why%20and%20where%20it%20occurs&journal=Nature%20Med.&doi=10.1038%2F90935&volume=7&pages=899-905&publication_year=2001&author=Marrack%2CP&author=Kappler%2CJ&author=Kotzin%2CBL?
• Profit of https://doi.org/10.1034%2Fj.1600-065X.2003.00010.x
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Thymic%20selection%20revisited%3A%20how%20essential%20is%20it%3F&journal=Immunol.%20Rev.&doi=10.1034%2Fj.1600-065X.2003.00010.x&volume=191&pages=62-78&publication_year=2003&author=von%20Boehmer%2CH?
• How much does https://doi.org/10.1016%2F0092-8674%2892%2990598-7 gross monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=ZAP-70%3A%20a%2070%E2%80%89kd%20protein-tyrosine%20kinase%20that%20associates%20with%20the%20TCR%20zeta%20chain&journal=Cell&doi=10.1016%2F0092-8674%2892%2990598-7&volume=71&pages=649-662&publication_year=1992&author=Chan%2CAC&author=Iwashima%2CM&author=Turck%2CCW&author=Weiss%2CA net monthly?
• Explore the financials of https://doi.org/10.1084%2Fjem.172.2.537
• How much does http://scholar.google.com/scholar_lookup?&title=Thymus%20and%20autoimmunity%3A%20capacity%20of%20the%20normal%20thymus%20to%20produce%20pathogenic%20self-reactive%20T%20cells%20and%20conditions%20required%20for%20their%20induction%20of%20autoimmune%20disease&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.172.2.537&volume=172&pages=537-545&publication_year=1990&author=Sakaguchi%2CS&author=Sakaguchi%2CN gross monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10228007 gross monthly?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Thymus%20and%20autoimmunity%3A%20production%20of%20CD25%2B%20CD4%2B%20naturally%20anergic%20and%20suppressive%20T%20cells%20as%20a%20key%20function%20of%20the%20thymus%20in%20maintaining%20immunologic%20self-tolerance&journal=J.%20Immunol.&volume=162&pages=5317-5326&publication_year=1999&author=Itoh%2CM
• https://doi.org/10.1038%2F376435a0's revenue stream
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995Natur.376..435N produce monthly?
• Profit of http://scholar.google.com/scholar_lookup?&title=Essential%20role%20for%20ZAP-70%20in%20both%20positive%20and%20negative%20selection%20of%20thymocytes&journal=Nature&doi=10.1038%2F376435a0&volume=376&pages=435-438&publication_year=1995&author=Negishi%2CI
• See how much https://doi.org/10.1038%2F79774 makes per month
• How much does http://scholar.google.com/scholar_lookup?&title=The%2021-%20and%2023-kD%20forms%20of%20TCR%20zeta%20are%20generated%20by%20specific%20ITAM%20phosphorylations&journal=Nature%20Immunol.&doi=10.1038%2F79774&volume=1&pages=322-328&publication_year=2000&author=van%20Oers%2CNS generate monthly?
• What's the total monthly financial gain of https://doi.org/10.1126%2Fscience.7509083?
• How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Sci...263.1136I generate?
• How much income does http://scholar.google.com/scholar_lookup?&title=Sequential%20interactions%20of%20the%20TCR%20with%20two%20distinct%20cytoplasmic%20tyrosine%20kinases&journal=Science&doi=10.1126%2Fscience.7509083&volume=263&pages=1136-1139&publication_year=1994&author=Iwashima%2CM have?
• How much income is https://doi.org/10.1016%2FS0092-8674%2800%2980901-0 earning monthly?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=LAT%3A%20the%20ZAP-70%20tyrosine%20kinase%20substrate%20that%20links%20T%20cell%20receptor%20to%20cellular%20activation&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980901-0&volume=92&pages=83-92&publication_year=1998&author=Zhang%2CW&author=Sloan-Lancaster%2CJ&author=Kitchen%2CJ&author=Trible%2CRP&author=Samelson%2CLE is on a monthly basis
• How profitable is https://doi.org/10.1016%2FS0952-7915%2800%2900224-7?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=MAP-kinase%20signaling%20pathway%20in%20T%20cells&journal=Curr.%20Opin.%20Immunol.&doi=10.1016%2FS0952-7915%2800%2900224-7&volume=13&pages=339-345&publication_year=2001&author=Rincon%2CM have monthly?
• Profit of https://doi.org/10.1074%2Fjbc.M908568199
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Alternative%20antigen%20receptor%20%28TCR%29%20signaling%20in%20T%20cells%20derived%20from%20ZAP-70-deficient%20patients%20expressing%20high%20levels%20of%20Syk&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M908568199&volume=275&pages=15832-15838&publication_year=2000&author=Noraz%2CN?
• How much income is https://doi.org/10.1126%2Fscience.2125367 earning monthly?
• Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Sci...250.1720M is on a monthly basis
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Induction%20by%20antigen%20of%20intrathymic%20apoptosis%20of%20CD4%2BCD8%2BTCRlo%20thymocytes%20in%20vivo&journal=Science&doi=10.1126%2Fscience.2125367&volume=250&pages=1720-1723&publication_year=1990&author=Murphy%2CKM&author=Heimberger%2CAB&author=Loh%2CDY?
• How much does https://doi.org/10.1038%2F333742a0 pull in monthly?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Natur.333..742K generate monthly?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Tolerance%20in%20T-cell-receptor%20transgenic%20mice%20involves%20deletion%20of%20nonmature%20CD4%2B8%2B%20thymocytes&journal=Nature&doi=10.1038%2F333742a0&volume=333&pages=742-746&publication_year=1988&author=Kisielow%2CP&author=Bluthmann%2CH&author=Staerz%2CUD&author=Steinmetz%2CM&author=von%20Boehmer%2CH
• Discover the revenue of https://doi.org/10.1038%2F335730a0
• Revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Natur.335..730K
• Revenue of http://scholar.google.com/scholar_lookup?&title=Positive%20selection%20of%20antigen-specific%20T%20cells%20in%20thymus%20by%20restricting%20MHC%20molecules&journal=Nature&doi=10.1038%2F335730a0&volume=335&pages=730-733&publication_year=1988&author=Kisielow%2CP&author=Teh%2CHS&author=Bluthmann%2CH&author=von%20Boehmer%2CH
• Income figures for https://doi.org/10.1016%2FS1074-7613%2800%2980442-2
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=A%20spontaneously%20arising%20mutation%20in%20the%20DLAARN%20motif%20of%20murine%20ZAP-70%20abrogates%20kinase%20activity%20and%20arrests%20thymocyte%20development&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980442-2&volume=6&pages=663-671&publication_year=1997&author=Wiest%2CDL have monthly?
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7636184
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Immunologic%20self-tolerance%20maintained%20by%20activated%20T%20cells%20expressing%20IL-2%20receptor%20%CE%B1-chains%20%28CD25%29.%20Breakdown%20of%20a%20single%20mechanism%20of%20self-tolerance%20causes%20various%20autoimmune%20diseases&journal=J.%20Immunol.&volume=155&pages=1151-1164&publication_year=1995&author=Sakaguchi%2CS&author=Sakaguchi%2CN&author=Asano%2CM&author=Itoh%2CM&author=Toda%2CM have monthly?
• How much does https://doi.org/10.1002%2Fj.1460-2075.1991.tb04978.x bring in each month?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Transgenic%20mice%20expressing%20human%20tumor%20necrosis%20factor%3A%20a%20predictive%20genetic%20model%20of%20arthritis&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1991.tb04978.x&volume=10&pages=4025-4031&publication_year=1991&author=Keffer%2CJ
• How much does https://doi.org/10.1016%2FS0092-8674%2800%2981989-3 make?
• http://scholar.google.com/scholar_lookup?&title=Organ-specific%20disease%20provoked%20by%20systemic%20autoimmunity&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981989-3&volume=87&pages=811-822&publication_year=1996&author=Kouskoff%2CV's revenue stream
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Chronic%20progressive%20polyarthritis%20and%20other%20symptoms%20of%20collagen%20vascular%20disease%20induced%20by%20graft-versus-host%20reaction&journal=J.%20Immunol.&volume=134&pages=1475-1482&publication_year=1985&author=Pals%2CST&author=Radaszkiewicz%2CT&author=Roozendaal%2CL&author=Gleichman%2CE?
• What's the income of https://doi.org/10.1016%2FS1074-7613%2800%2980089-8?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Development%20of%20lupus-like%20autoimmune%20diseases%20by%20disruption%20of%20the%20PD-1%20gene%20encoding%20an%20ITIM%20motif-carrying%20immunoreceptor&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980089-8&volume=11&pages=141-151&publication_year=1999&author=Nishimura%2CH&author=Nose%2CM&author=Hiai%2CH&author=Minato%2CN&author=Honjo%2CT bring in?
• How much income is https://doi.org/10.1084%2Fjem.191.2.313 earning monthly?
• http://scholar.google.com/scholar_lookup?&title=Development%20of%20chronic%20inflammatory%20arthropathy%20resembling%20rheumatoid%20arthritis%20in%20interleukin%201%20receptor%20antagonist-deficient%20mice&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.191.2.313&volume=191&pages=313-320&publication_year=2000&author=Horai%2CR's financial summary
• What's the profit of https://doi.org/10.1084%2Fjem.20020619?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=A%20point%20mutation%20of%20Tyr-759%20in%20interleukin%206%20family%20cytokine%20receptor%20subunit%20gp130%20causes%20autoimmune%20arthritis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20020619&volume=196&pages=979-990&publication_year=2002&author=Atsumi%2CT?
• What are the total earnings of https://link.springer.com/doi/10.1186/ar5?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Cytokines%20and%20direct%20cell%20contact%20in%20synovitis%3A%20relevance%20to%20therapeutic%20intervention&journal=Arthritis%20Res.&doi=10.1186%2Far5&volume=1&pages=17-20&publication_year=1999&author=Dayer%2CJM&author=Burger%2CD?
• What's the income generated by https://link.springer.com/doi/10.1186/ar565 each month?
• What's http://scholar.google.com/scholar_lookup?&title=The%20paradigm%20of%20IL-6%3A%20from%20basic%20science%20to%20medicine&journal=Arthritis%20Res.&doi=10.1186%2Far565&volume=4&pages=S233-S242&publication_year=2002&author=Naka%2CT&author=Nishimoto%2CN&author=Kishimoto%2CT's gross income?
• Financial intake of https://doi.org/10.1126%2Fscience.1067833
• Revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2003Sci...299.1859W
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Signaling%20life%20and%20death%20in%20the%20thymus%3A%20timing%20is%20everything&journal=Science&doi=10.1126%2Fscience.1067833&volume=299&pages=1859-1863&publication_year=2003&author=Werlen%2CG&author=Hausmann%2CB&author=Naeher%2CD&author=Palmer%2CE
• How much does https://doi.org/10.1002%2F1529-0131%28200106%2944%3A6%3C1336%3A%3AAID-ART226%3E3.0.CO%3B2-8 bring in each month?
• How much does http://scholar.google.com/scholar_lookup?&title=T%20cell%20signalling%20abnormalities%20in%20systemic%20lupus%20erythematosus%20are%20associated%20with%20increased%20mutations%2Fpolymorphisms%20and%20splice%20variants%20of%20T%20cell%20receptor%20zeta%20chain%20messenger%20RNA&journal=Arthritis%20Rheum.&doi=10.1002%2F1529-0131%28200106%2944%3A6%3C1336%3A%3AAID-ART226%3E3.0.CO%3B2-8&volume=44&pages=1336-1350&publication_year=2001&author=Nambiar%2CMP net monthly?
• How much does https://doi.org/10.1093%2Fintimm%2F10.7.911 pull in monthly?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=TCR%20zeta%20chain%20lacking%20exon%207%20in%20two%20patients%20with%20systemic%20lupus%20erythematosus&journal=Int.%20Immunol.&doi=10.1093%2Fintimm%2F10.7.911&volume=10&pages=911-921&publication_year=1998&author=Takeuchi%2CT
• Revenue of https://citation-needed.springer.com/v2/references/10.1038/nature02119?format=refman&flavour=references
• Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Noriko%20Sakaguchi
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Noriko%20Sakaguchi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takeshi%20Takahashi
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takeshi%20Takahashi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hiroshi%20Hata make?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hiroshi%20Hata%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takashi%20Nomura generate?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takashi%20Nomura%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tomoyuki%20Tagami
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tomoyuki%20Tagami%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sayuri%20Yamazaki earning monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sayuri%20Yamazaki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Toshiko%20Sakihama generate monthly?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Toshiko%20Sakihama%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takaji%20Matsutani?
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takaji%20Matsutani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Izumi%20Negishi rake in every month?
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Izumi%20Negishi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Syuichi%20Nakatsuru?
• Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Syuichi%20Nakatsuru%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shimon%20Sakaguchi rake in every month?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shimon%20Sakaguchi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM1_ESM.jpg earn?
• How much income does https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM2_ESM.jpg have?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM3_ESM.jpg bring in?
• How much income is https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM4_ESM.jpg earning monthly?
• See how much https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM5_ESM.jpg makes per month
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM6_ESM.jpg income
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature02119/MediaObjects/41586_2003_BFnature02119_MOESM7_ESM.doc's revenue stream
• https://s100.copyright.com/AppDispatchServlet?title=Altered%20thymic%20T-cell%20selection%20due%20to%20a%20mutation%20of%20the%20ZAP-70%20gene%20causes%20autoimmune%20arthritis%20in%20mice&author=Noriko%20Sakaguchi%20et%20al&contentID=10.1038%2Fnature02119©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=2003-11-27&publisherName=SpringerNature&orderBeanReset=true income
• https://citation-needed.springer.com/v2/references/10.1038/nature02119?format=refman&flavour=citation's total income per month
• What's the monthly money flow for https://doi.org/10.1038/s41584-024-01081-0?
• What's the income generated by https://doi.org/10.1007/s00109-024-02428-6 each month?
• Find out how much https://doi.org/10.1186/s13075-023-03069-9 earns monthly
• What's the revenue for https://doi.org/10.1186/s12951-023-01906-2?
• What's the revenue for https://doi.org/10.1186/s42234-023-00126-1?
• See how much https://www.protocols.io/ makes per month
• What's the income generated by https://www.natureindex.com/ each month?
• Find out how much http://www.naturechina.com earns monthly
• Profit of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref