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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://www.nature.com/articles/335730a0, but it redirected us to https://www.nature.com/articles/335730a0. The analysis below is for the second page.

Title[redir]:
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules | Nature
Description:
Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.

Matching Content Categories {📚}

  • Science
  • Education
  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, nature, google, scholar, cas, ads, cells, access, mhc, content, class, cookies, selection, molecules, kisielow, teh, tcr, privacy, boehmer, immunology, data, positive, antigenspecific, thymus, thymic, bevan, immun, proc, research, advertising, information, subscribe, restricting, pawel, hung, sia, blüthmann, binding, institution, learn, buy, open, cell, natn, acad, sci, usa, exp, med, immunogenetics,

Topics {✒️}

nature portfolio permissions reprints privacy policy t-cell development advertising social media subscribe nature hung sia teh nature 320 nature 325 nature 328 nature 335 nature 333 nature 269 nature 292 nature 332 nature personal data cell central tolerance springerlink instant access data protection permissions von boehmer thymic mhc molecules privacy restricting mhc molecules article kisielow explore content subscription content cds molecules expressed mhc-restricted cd4−8+ european economic area major histocompatibility complex αβ tcr expressed provide direct evidence issue learn institutional subscriptions read hoffmann–la roche accepting optional cookies tcr transgenic mice cd4/cd8 phenotype immature cd4+8+ thymocytes cd4 improve detection journals search log cells article 03 manage preferences immune system learn class ii content article purchase

Questions {❓}

  • How does the immune system learn to distinguish between good and evil?

Schema {🗺️}

WebPage:
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         headline:Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
         description:Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
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      headline:Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
      description:Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
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                     type:PostalAddress
                  type:Organization
                  name:Polish Academy of Sciences
                  address:
                     name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
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            name:Hung Sia Teh
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                  name:Basel Institute for Immunology
                  address:
                     name:Basel Institute for Immunology, Basel, Switzerland
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            address:
               name:Basel Institute for Immunology, Basel, Switzerland
               type:PostalAddress
            type:Organization
            name:University of British Columbia
            address:
               name:Department of Microbiology, University of British Columbia, Vancouver, Canada
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            name:F. Hoffmann–La Roche & Co. Ltd
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               name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
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Social Networks {👍}(2)

External Links {🔗}(169)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.01s.