We are analyzing https://link.springer.com/article/10.1186/ar565.

Title:
The paradigm of IL-6: from basic science to medicine | Arthritis Research & Therapy
Description:
IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared by IL-6-related cytokines such as leukemia inhibitory factor and oncostatin M. The pleiotropy and redundancy of IL-6 functions have been identified by using a unique receptor system comprising two functional proteins: an IL-6 receptor (IL-6R) and gp130, the common signal transducer of cytokines related to IL-6. Signal transduction through gp130 is mediated by two pathways: the JAK–STAT (Janus family tyrosine kinase–signal transducer and activator of transcription) pathway and the Ras mitogen-activated protein kinase pathway. The negative regulators of IL-6 signaling have also been identified, although the physiological roles of the molecules are not yet fully understood. The pathological roles of IL-6 have also been clarified in various disease conditions, such as inflammatory, autoimmune, and malignant diseases. On the basis of the findings, a new therapeutic approach to block the IL-6 signal using humanized anti-IL-6R antibody for rheumatoid arthritis, Castleman
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Keywords {🔍}

pubmed, google, scholar, factor, signal, stat, cytokine, interleukin, cells, kishimoto, cell, socs, signaling, human, central, receptor, protein, antibody, hirano, growth, family, tyrosine, mice, sci, arthritis, activation, transduction, proc, natl, acad, usa, differentiation, cytokines, humanized, jak, immunol, proteins, expression, ilr, transducer, antiilr, rheumatoid, pias, activated, receptors, response, shp, inhibits, taga, science,

Topics {✒️}

monocyte-derived hepatocyte-stimulating factor humanized anti-il-6r antibody il-6 vitamin-d-binding protein multiple b-lymphotropic lymphokines c-terminal socs-box form granulocyte colony-stimulatory factor granulocyte-colony-stimulating factor granulocyte colony-stimulating factor socs-3-deficient mice showed cell-specific stat3-deficient mice vivo inhibits tnf-α ras mitogen-activated protein anti-il-6r antibody signal-transducing receptor component stat3-mediated gene transcriptions t-cell-specific manner lymphocyte-dependent perinatal lethality acute-phase response factor acute-phase response elements stat-induced stat inhibitor disease-modifying antirheumatic drugs putative zinc-binding motif type ii il-6re gp130-induced cell growth myeloid cell line il-6r induces homodimerization acute-phase protein synthesis modular tyrosine-based motifs produce acute-phase proteins soluble il-6r acts dysregulated cross-talk inhibition gp130-mediated terminal differentiation il-6-induced macrophage differentiation il-6-induced growth arrest ifn-γ-induced inhibition gp130-mediated signaling pathway hepatocyte-stimulating factor [11–13] hepatocyte-stimulating factor 65-amino-acid region proximal 80-kda il-6-binding protein socs-3-deficient mice die socs-1-deficient mice feature il-6/il-6r/gp130 cell-stimulatory factor 2 cell stimulatory factor-2 full size image nf-il-6 gene bsf-2/inf b2 ifn-γ gene tumor necrosis factor

Schema {🗺️}

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         description:IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared by IL-6-related cytokines such as leukemia inhibitory factor and oncostatin M. The pleiotropy and redundancy of IL-6 functions have been identified by using a unique receptor system comprising two functional proteins: an IL-6 receptor (IL-6R) and gp130, the common signal transducer of cytokines related to IL-6. Signal transduction through gp130 is mediated by two pathways: the JAK–STAT (Janus family tyrosine kinase–signal transducer and activator of transcription) pathway and the Ras mitogen-activated protein kinase pathway. The negative regulators of IL-6 signaling have also been identified, although the physiological roles of the molecules are not yet fully understood. The pathological roles of IL-6 have also been clarified in various disease conditions, such as inflammatory, autoimmune, and malignant diseases. On the basis of the findings, a new therapeutic approach to block the IL-6 signal using humanized anti-IL-6R antibody for rheumatoid arthritis, Castleman's disease, and multiple myeloma has been attempted.
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      headline:The paradigm of IL-6: from basic science to medicine
      description:IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared by IL-6-related cytokines such as leukemia inhibitory factor and oncostatin M. The pleiotropy and redundancy of IL-6 functions have been identified by using a unique receptor system comprising two functional proteins: an IL-6 receptor (IL-6R) and gp130, the common signal transducer of cytokines related to IL-6. Signal transduction through gp130 is mediated by two pathways: the JAK–STAT (Janus family tyrosine kinase–signal transducer and activator of transcription) pathway and the Ras mitogen-activated protein kinase pathway. The negative regulators of IL-6 signaling have also been identified, although the physiological roles of the molecules are not yet fully understood. The pathological roles of IL-6 have also been clarified in various disease conditions, such as inflammatory, autoimmune, and malignant diseases. On the basis of the findings, a new therapeutic approach to block the IL-6 signal using humanized anti-IL-6R antibody for rheumatoid arthritis, Castleman's disease, and multiple myeloma has been attempted.
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      dateModified:2002-05-09T00:00:00Z
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         rheumatoid arthritis
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