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pubmed, cell, article, bcl, google, scholar, cas, apoptosis, proteins, stress, family, death, bax, central, calcium, protein, mitochondrial, membrane, bhonly, autophagy, regulation, bak, biol, release, endoplasmic, control, reticulum, signaling, upr, response, activation, members, mitochondria, proapoptotic, tmbim, bok, mol, nature, pathway, activity, figure, antiapoptotic, chem, momp, role, ireα, hetz, permeabilization, homeostasis, sci,

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Questions {❓}

• Are TMBIM proteins ion channels?
• Do BCL-2-related proteins modulate the switch between proadaptive to proapoptotic ER stress responses?
• How does ER permeabilization lead to cell death?
• What is the functional relationship between proteins of the BCL-2 and TMBIM families in the regulation of cell death?
• What is the relationship between the TMBIM and the BCL-2 protein family?

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