
PMC . NCBI . NLM . NIH . GOV {
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Title:
Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart - PMC
Description:
Opening of the mitochondrial permeability transition pore (MPTP) is thought to be a critical event in mediating the damage to hearts that accompanies their reperfusion following prolonged ischaemia. Protection from reperfusion injury occurs if the ...
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27 years and 8 months (reg. 1997-10-02).
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Keywords {🔍}
hearts, doi, mptp, opening, mitochondrial, ipc, mitochondria, reperfusion, heart, hdog, data, sfa, pubmed, google, scholar, halestrap, control, csa, entrapment, ischaemia, min, pore, recovery, experiments, permeability, injury, dog, shown, transition, preconditioning, calcium, conditions, lvdp, ldh, fig, griffiths, inhibition, isolated, protection, release, postloading, ischaemic, pmc, total, loading, perfusion, function, technique, kerr, free,
Topics {✒️}
org/cgi/content/full/549/2/513 doi atp-sensitive potassium channels mitochondrial k-atp channels mitochondrial 2-deoxy[3h]glucose entrapment o-18-assisted p-31 nmr post-loading technique [3h]dog pmc beta search mitochondrial adp/atp carrier pmc copyright notice water-filled balloon inserted total [3h]dog content coronary occlusion-reperfusion model 2-deoxy[3h]glucose-6-phosphate free radical production total [3h]dog loading mitochondrial [3h]dog entrapment post-loaded [3h]dog pre-loaded [3h]dog mitochondrial dog-entrapment technique total heart [3h]dog enhance [3h]dog conversion slow mptp-independent uptake post-loading technique failed dog pre-loading technique reactive oxygen species post-loading protocol correlates dog post-loading experiments british heart foundation dog pre-loading experiments global ischaemia-reperfusion model krebs-henseleit solution supplementary materials included mitochondrial permeability transition matrix volume induced free [ca2+] shown license information pmcid permeability transition pore causing mitochondrial depolarization 2-deoxy[3h]glucose 2-deoxy[3h] glucose post-loading data show continuing atp deprivation isolated de-energised mitochondria correlations held true references baines cp mitochondrial [3h]dog full-blown necrosis ischemia reperfusion-induced damage buffered calcium concentrations [3h]dog entrapment
Questions {❓}
- Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
- Mitochondria: a new target for K+ channel openers?
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