
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels - PMC
Description:
The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane mediates metabolic flow, Ca2+, and cell death signaling between the endoplasmic reticulum (ER) and mitochondrial networks. We demonstrate that VDAC1 is physically linked ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Matching Content Categories {📚}
- Education
- Science
- Technology & Computing
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Custom-built
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
mitochondrial, grp, pubmed, google, scholar, doi, protein, ipr, iprlbd, cells, vdac, effect, uptake, fig, cell, shown, pmc, mitochondria, article, cam, domain, free, proteins, omm, biol, control, fraction, membrane, mam, molecular, interaction, cac, complex, data, channel, expression, matrix, hela, reticulum, channels, rizzuto, controls, cytosolic, biochem, endoplasmic, stimulatory, release, interactions, previously, role,
Topics {✒️}
kidney lexa-ad–fused libraries org/cgi/content/full/jcb voltage-dependent anion-selective channel serca blocker tert-butyl-benzohydroquinone steady-state [ca2+]er level omm-ip3r-lbd224-605 /grp75cyt–expressing cells mortalin/grp75/peptide-binding protein 74 voltage-dependent anion channel marie-curie individual fellowship n-terminal repressor domain mrfp1-fused ip3r-lbd224-605 constructs ip3r-lbd224-605–expressing cells showed c-terminal domain reduced heat-shock protein pbp74 n-terminal akap1 domain histamine-/ip3-induced ca2+ release emilia-romagna programma regionale omm-ip3-lbd1-604-mrfp1 construct sds-page 2d separation omm-ip3r-lbd224-605–expressing cells sds-page protein separation omm-targeted ip3r-lbd domain full-length mouse ip3r-1 pmc copyright notice omm targeted n-terminal n-terminal cytosolic domain omm-targeted p130-ph domain af052659 tubulin-specific chaperone ca2+-phosphate precipitation technique grp75/mthsp70/pbp74/mortalin overexpression k508a omm-ip3r-lbd224-605 increased online supplemental material pmc beta search omm-ip3r-lbd224-605–cotransfected cells omm-ip3r-lbd224-605 cotransfected cells steady-state er [ca2+] steady-state [ca2+]er omm-ip3r-lbd224-605–transfected cells lethal interorganelle cross-talk steady [ca2+]er level ip3-induced ca2+ release ip3-insensitive ip3r-lbd224-605 isotype-specific monoclonal antibody ip3r ligand-binding domain er–mitochondrial interface outlined ip3r-lbd–induced augmentation mortalin/mthsp70/pbp74/grp75 preserve er–mitochondrial contacts er ca2+-handling machinery er-ip3r-lbd224-605-mrfp1
Questions {❓}
- An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?
- How is the newly identified regulatory activity on mitochondrial Ca2+ uptake exerted?
- Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?
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