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Title:
VDAC2 inhibits BAK activation and mitochondrial apoptosis - PubMed
Description:
The multidomain proapoptotic molecules BAK or BAX are required to initiate the mitochondrial pathway of apoptosis. How cells maintain the potentially lethal proapoptotic effector BAK in a monomeric inactive conformation at mitochondria is unknown. In viable cells, we found BAK complexed with mitocho …
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Keywords {🔍}
protein, proteins, vdac, bak, doi, mitochondrial, pmid, apoptosis, bax, cells, voltagedependent, anion, metabolism, mitochondria, free, pmc, mouse, death, article, human, cited, channel, review, articles, mesh, bcl, cell, epub, channels, research, pharmacology, membrane, porins, protooncogene, main, states, ncbi, similar, resources, science, activation, proapoptotic, pathway, isoform, apoptotic, pubmed, release, cytochrome, biol, apr,
Topics {✒️}
united states government mitochondrial channel vdac main page content similar articles cited mouse bid protein human vdac1 protein mouse vdac2 protein mouse bax protein cell death differ funding linkout protein protein bcl-2 bcl human bak1 protein human vdac2 protein agrobacterium-mediated genetic transformation human bax protein monomeric inactive conformation books gene gene death signals activate mesh keyword pubchem substance grants mitochondrial apoptosis emily apoptotic death bak-mediated apoptosis abundant vdac1 bh3 cell metab mol cells mitochondrial apoptotic pathway enabling homo-oligomerization resources science vdac isoform present hhs 1083995 abstract medgen nucleotide omim research materials addgene core apoptotic pathway found bak complexed cells maintain viable cells cells deficient cells lacking cancer cells binding research support cited mitochondrial pathway bax activation biology
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