We are analyzing https://link.springer.com/article/10.1186/s40880-018-0288-x.

Title:
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer | Cancer Communications
Description:
Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.
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Keywords {🔍}

slca, cancer, pubmed, cells, cell, scholar, google, cas, cystine, glucose, stress, expression, glutamine, dependency, amino, system, glutamate, death, acid, central, nutrient, glutathione, conditions, oxidative, ferroptosis, metabolism, studies, transport, atf, article, cysteine, fig, nrf, intracellular, starvation, cystineglutamate, response, activity, redox, tumor, functions, regulating, inhibition, protein, gsh, deprivation, transporter, metabolic, including, recent,

Topics {✒️}

receptor-interacting serine/threonine-protein kinase nonsense-mediated mrna decay cystine/glutamate transporter-deficient mice p62-keap1-nrf2 pathway protects gcn2-eif2α-atf4 signaling axis slc7a11-mediated cystine/glutamate exchange keap1-cullin3-mediated polyubiquitination kras-regulated metabolic pathway reduce peroxide-related products serine/threonine kinase consisting cystine-glutamate antiporter xct article download pdf cystine/glutamate antiporter consisting called γ-glutamylcysteine synthetase slc7a11-mediated glutamate export li zhuang & boyi gan cystine/glutamate transporter gene γgcs γ-glutamylcysteine synthetase cystine/glutamate antiporter activity slc7a11-mediated transport activity fine-tune cellular responses cystine transporter slc7a11/xct bax/bak-deficient cells lipid-ooh lipid hydroperoxide n-terminal cytoplasmic tail gst glutathione s-transferase slc7a11-mediated cystine uptake cystine/glutamate exchanger slc7a11 cystine/glutamate antiporter system human cystine/glutamate transporter micrornas including mir-27a generates γ-glutamyl-cysteine slc7a11-mediated redox homeostasis stress-induced slc7a11 expression central carbon metabolism chronic lymphocytic leukaemia inhibiting cell survival/growth cell-line-dependent manner open questions remain full access revealed pro-death functions amino acid metabolism amino acid transporter cell death induced mitochondrial pyruvate carrier cystine/glutamate antiporter �� cystine/glutamate antiporter remains largely unknown inducing xct expression ferroptotic cell death

Questions {❓}

(i) How does SLC7A11 regulate nutrient dependency in cancer cells?
A fundamental defect in metabolism?

Schema {🗺️}

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         headline:Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
         description:Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.
         datePublished:2018-04-25T00:00:00Z
         dateModified:2018-04-25T00:00:00Z
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      headline:Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
      description:Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.
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         Glutamate
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         Oxidative stress
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         Cancer metabolism
         Cancer Research
         Oncology
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      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
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      name:The University of Texas Graduate School of Biomedical Sciences, Houston, USA
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