We are analyzing https://link.springer.com/article/10.1186/s40164-022-00277-y.

Title:
Heterogeneity of the tumor immune microenvironment and its clinical relevance | Experimental Hematology & Oncology
Description:
During the course of tumorigenesis and subsequent metastasis, malignant cells gradually diversify and become more heterogeneous. Consequently, the tumor mass might be infiltrated by diverse immune-related components, including the cytokine/chemokine environment, cytotoxic activity, or immunosuppressive elements. This immunological heterogeneity is universally presented spatially or varies temporally along with tumor evolution or therapeutic intervention across almost all solid tumors. The heterogeneity of anti-tumor immunity shows a profound association with the progression of disease and responsiveness to treatment, particularly in the realm of immunotherapy. Therefore, an accurate understanding of tumor immunological heterogeneity is essential for the development of effective therapies. Facilitated by multi-regional and -omics sequencing, single cell sequencing, and longitudinal liquid biopsy approaches, recent studies have demonstrated the potential to investigate the complexity of immunological heterogeneity of the tumors and its clinical relevance in immunotherapy. Here, we aimed to review the mechanism underlying the heterogeneity of the immune microenvironment. We also explored how clinical assessments of tumor heterogeneity might facilitate the development of more effective personalized therapies.
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Keywords {🔍}

pubmed, article, google, scholar, cas, tumor, cell, immune, cancer, heterogeneity, central, cells, microenvironment, patients, response, nat, tumors, immunotherapy, evolution, spatial, lung, heterogeneous, genetic, neoantigens, treatment, med, clonal, immunological, expression, nature, therapy, therapeutic, progression, blockade, sequencing, checkpoint, resistance, antigen, immunotherapies, antitumor, clones, immunogenic, pdl, immunol, including, clinical, immunity, mutations, intratumoral, neoantigen,

Topics {✒️}

car-t-treated b-cell nhl anti-cd19-car t-cell therapy bi-specific cd19/cd22 car deletion-derived tumour-specific neoantigens expanded/proliferative t-cell receptors single-cell transcriptome analysis pd-l1-negative neoplasms respond shared immunogenic poly-epitopes article download pdf intra-individually metastasized tumors car t-cell therapy high-throughput sequencing approaches car t-cell activity targeted anti-cancer drugs pd-l1-positive tumors fail enhance t-cell function single-cell rna sequencing early-stage breast cancer genetic intra-tumor heterogeneity phylogenetic ctdna analysis tumour micro-environment heterogeneity cell-programmed nutrient partitioning multi-regional sequencing elucidates small-cell lung cancer pre-existing neoantigen-specific anti-tumor immunity shows cd68+cd163+cd206+ phenotype lisocabtagene maraleucel-treated patients multi-region sequencing unveils tumor-cell intrinsic genotype neoantigen-directed immune escape evaluating pd-l1 expression oncogenic cancer/testis antigens diverse immune-related components antigen-specific fas+ cd8+ heterogeneous tumor-immune microenvironments rna vaccines coding anti-tumor immunity independent autophagy-dependent atp release indicating immuno-pressure purification allele-specific hla loss anti-tumor immune response de massy mr interferon-γ pathway failed microsatellite-stable solid tumors bi-specific car treatment-related survival pressure ith-related variables affecting single modified car keskin db

Schema {🗺️}

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         description:During the course of tumorigenesis and subsequent metastasis, malignant cells gradually diversify and become more heterogeneous. Consequently, the tumor mass might be infiltrated by diverse immune-related components, including the cytokine/chemokine environment, cytotoxic activity, or immunosuppressive elements. This immunological heterogeneity is universally presented spatially or varies temporally along with tumor evolution or therapeutic intervention across almost all solid tumors. The heterogeneity of anti-tumor immunity shows a profound association with the progression of disease and responsiveness to treatment, particularly in the realm of immunotherapy. Therefore, an accurate understanding of tumor immunological heterogeneity is essential for the development of effective therapies. Facilitated by multi-regional and -omics sequencing, single cell sequencing, and longitudinal liquid biopsy approaches, recent studies have demonstrated the potential to investigate the complexity of immunological heterogeneity of the tumors and its clinical relevance in immunotherapy. Here, we aimed to review the mechanism underlying the heterogeneity of the immune microenvironment. We also explored how clinical assessments of tumor heterogeneity might facilitate the development of more effective personalized therapies.
         datePublished:2022-04-23T00:00:00Z
         dateModified:2022-04-23T00:00:00Z
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            Heterogeneity
            Immune checkpoint blockade
            Immunotherapy
            Hematology
            Oncology
            Cancer Research
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      headline:Heterogeneity of the tumor immune microenvironment and its clinical relevance
      description:During the course of tumorigenesis and subsequent metastasis, malignant cells gradually diversify and become more heterogeneous. Consequently, the tumor mass might be infiltrated by diverse immune-related components, including the cytokine/chemokine environment, cytotoxic activity, or immunosuppressive elements. This immunological heterogeneity is universally presented spatially or varies temporally along with tumor evolution or therapeutic intervention across almost all solid tumors. The heterogeneity of anti-tumor immunity shows a profound association with the progression of disease and responsiveness to treatment, particularly in the realm of immunotherapy. Therefore, an accurate understanding of tumor immunological heterogeneity is essential for the development of effective therapies. Facilitated by multi-regional and -omics sequencing, single cell sequencing, and longitudinal liquid biopsy approaches, recent studies have demonstrated the potential to investigate the complexity of immunological heterogeneity of the tumors and its clinical relevance in immunotherapy. Here, we aimed to review the mechanism underlying the heterogeneity of the immune microenvironment. We also explored how clinical assessments of tumor heterogeneity might facilitate the development of more effective personalized therapies.
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      dateModified:2022-04-23T00:00:00Z
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      pageEnd:14
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      sameAs:https://doi.org/10.1186/s40164-022-00277-y
      keywords:
         Tumor microenvironment
         Heterogeneity
         Immune checkpoint blockade
         Immunotherapy
         Hematology
         Oncology
         Cancer Research
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               type:PostalAddress
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               type:PostalAddress
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               type:PostalAddress
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            address:
               name:Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital, Army Medical University, Chongqing, China
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      name:Haixia Long
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               type:PostalAddress
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      name:Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital, Army Medical University, Chongqing, China
      name:Institute of Cancer, Xinqiao Hospital, Army Military Medical University, Chongqing, China
      name:Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital, Army Medical University, Chongqing, China
      name:Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China
      name:Institute of Cancer, Xinqiao Hospital, Army Military Medical University, Chongqing, China
      name:Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital, Army Medical University, Chongqing, China
      name:Institute of Cancer, Xinqiao Hospital, Army Military Medical University, Chongqing, China
      name:Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital, Army Medical University, Chongqing, China

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