We are analyzing https://link.springer.com/article/10.1186/s13059-017-1348-2.

Title:
The multidimensional mechanisms of long noncoding RNA function | Genome Biology
Description:
A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Photography

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cas, rna, noncoding, lncrnas, gene, lncrna, central, long, transcription, rnas, cell, expression, proteins, genes, dna, chromatin, transcriptional, regulation, function, nuclear, genome, protein, formation, binding, mol, biol, nat, functional, human, shown, activity, nature, neat, interactions, fig, complex, silencing, enhancer, mechanisms, functions, enhancers, regulate, paraspeckles, including, role, involved,

Topics {✒️}

men epsilon/beta nuclear-retained trithorax-group/mixed-lineage leukemia liquid-phase separation dependent lncrna binds nf-κb/iκb rna–dna triplex-dependent manner lncrna-mediated inter-chromosomal interactions article download pdf gonadotropin alpha-subunit gene r-loop-dependent transcriptional repression menepsilon/beta noncoding rnas regulates locus-specific methylation telomere-length-dependent manner [72] modulates p53-induced transactivation prevents py705-stat3 dephosphorylation polycomb/trithorax epigenetic switch dna-binding core domain triplex-forming long ncrna vivo triplex-capture assays form sense-antisense pairs androgen receptor-driven looping pregnancy-induced noncoding rna displaced single-stranded dna observed ligand-dependent induction rna–dna triplexes mediate hotair-mediated transcriptional repression sense–antisense paired genes p53-mediated gene expression tgf-beta pathway genes rna–dna triplexes formed closest protein-coding gene involves linc-dc interaction oestrogen-dependent transcriptional activation sister-chromatid cohesion sister-chromatid cohesion [55] rna-dna triplex structures vernalization-mediated epigenetic silencing protein-coding genes analyzed abundant mono-exonic lncrna rna-dna triplex formation proto-oncogene sphk1 kim tk tissue-specific lncrna fendrr o'malley bw exert cis-regulatory activities androgen-receptor-regulated enhancers [92] long noncoding rna tumour suppressor p53 full access mammalian mrna-binding proteins 7-kb neat1_1 isoform

Questions {❓}

Nuclear organization in the 3D space of the nucleus--cause or consequence?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The multidimensional mechanisms of long noncoding RNA function
         description:A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes.
         datePublished:2017-10-31T00:00:00Z
         dateModified:2017-10-31T00:00:00Z
         pageStart:1
         pageEnd:13
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13059-017-1348-2
         keywords:
            lncRNAs
            Paraspeckles
            Polycomb Repressive Complex 2 (PRC2)
            Negative Elongation Factor (NELF)
            Signal Transducer And Activator Of Transcription (STAT3)
            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig5_HTML.gif
         isPartOf:
            name:Genome Biology
            issn:
               1474-760X
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Francesco P. Marchese
               affiliation:
                     name:University of Navarra, Center for Applied Medical Research (CIMA)
                     address:
                        name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Institute of Health Research of Navarra (IdiSNA)
                     address:
                        name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ivan Raimondi
               affiliation:
                     name:University of Navarra, Center for Applied Medical Research (CIMA)
                     address:
                        name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Institute of Health Research of Navarra (IdiSNA)
                     address:
                        name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maite Huarte
               affiliation:
                     name:University of Navarra, Center for Applied Medical Research (CIMA)
                     address:
                        name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Institute of Health Research of Navarra (IdiSNA)
                     address:
                        name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The multidimensional mechanisms of long noncoding RNA function
      description:A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes.
      datePublished:2017-10-31T00:00:00Z
      dateModified:2017-10-31T00:00:00Z
      pageStart:1
      pageEnd:13
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13059-017-1348-2
      keywords:
         lncRNAs
         Paraspeckles
         Polycomb Repressive Complex 2 (PRC2)
         Negative Elongation Factor (NELF)
         Signal Transducer And Activator Of Transcription (STAT3)
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-017-1348-2/MediaObjects/13059_2017_1348_Fig5_HTML.gif
      isPartOf:
         name:Genome Biology
         issn:
            1474-760X
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Francesco P. Marchese
            affiliation:
                  name:University of Navarra, Center for Applied Medical Research (CIMA)
                  address:
                     name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Institute of Health Research of Navarra (IdiSNA)
                  address:
                     name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ivan Raimondi
            affiliation:
                  name:University of Navarra, Center for Applied Medical Research (CIMA)
                  address:
                     name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Institute of Health Research of Navarra (IdiSNA)
                  address:
                     name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maite Huarte
            affiliation:
                  name:University of Navarra, Center for Applied Medical Research (CIMA)
                  address:
                     name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Institute of Health Research of Navarra (IdiSNA)
                  address:
                     name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Genome Biology
      issn:
         1474-760X
      volumeNumber:18
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Navarra, Center for Applied Medical Research (CIMA)
      address:
         name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
         type:PostalAddress
      name:Institute of Health Research of Navarra (IdiSNA)
      address:
         name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
         type:PostalAddress
      name:University of Navarra, Center for Applied Medical Research (CIMA)
      address:
         name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
         type:PostalAddress
      name:Institute of Health Research of Navarra (IdiSNA)
      address:
         name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
         type:PostalAddress
      name:University of Navarra, Center for Applied Medical Research (CIMA)
      address:
         name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
         type:PostalAddress
      name:Institute of Health Research of Navarra (IdiSNA)
      address:
         name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Francesco P. Marchese
      affiliation:
            name:University of Navarra, Center for Applied Medical Research (CIMA)
            address:
               name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
               type:PostalAddress
            type:Organization
            name:Institute of Health Research of Navarra (IdiSNA)
            address:
               name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
               type:PostalAddress
            type:Organization
      name:Ivan Raimondi
      affiliation:
            name:University of Navarra, Center for Applied Medical Research (CIMA)
            address:
               name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
               type:PostalAddress
            type:Organization
            name:Institute of Health Research of Navarra (IdiSNA)
            address:
               name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
               type:PostalAddress
            type:Organization
      name:Maite Huarte
      affiliation:
            name:University of Navarra, Center for Applied Medical Research (CIMA)
            address:
               name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
               type:PostalAddress
            type:Organization
            name:Institute of Health Research of Navarra (IdiSNA)
            address:
               name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
      name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
      name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
      name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain
      name:University of Navarra, Center for Applied Medical Research (CIMA), Pamplona, Spain
      name:Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain

External Links {🔗}(464)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.98s.

LINK . SPRINGER . COM {}