
NCBI . NLM . NIH . GOV {
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Title[redir]:
A long noncoding RNA induced by TLRs mediates both activation and repression of immune response genes - PMC
Description:
An inducible program of inflammatory gene expression is central to anti-microbial defenses. Signal-dependent activation of transcription factors, transcriptional co-regulators and chromatin modifying factors collaborate to control this response. ...
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Keywords {🔍}
lincrnacox, doi, genes, fig, expression, cells, tlr, hnrnpab, rna, pubmed, google, scholar, pmc, article, immune, free, lncrnas, response, levels, ccl, macrophages, cell, pamcsk, gene, table, induced, noncoding, inflammatory, transcription, signaling, transcriptional, stimulation, analysis, stimulated, shrna, control, data, silenced, silencing, nuclear, irf, protein, knockdown, long, bmdms, qrtpcr, mrna, nature, nlm, science,
Topics {✒️}
hnrnp-a2/b1 promotes recruitment hrb/marie curie fellowship vitro-transcribed biotinylated lincrna-cox2 endotoxin-mediated macrophage expression pmc beta search conserved multi-exonic structure macrophages nihms668565-supplement-supplemntals ribosome-protected mrna fragments ifn α/βr ko interferon α/β receptor anti-microbial defenses endotoxin-stimulated murine macrophages signal-dependent transcriptional elongation expressed lincrna-cox2 reversed ectopically expressed lincrna-cox2 lincrna-cox2 knockdown cells /b-type hnrnp cbf rna-related biological processes long noncoding rna supplementary materials included lincrna-cox2 regulates transcription rna pol ii p53-dependent transcriptional response long noncoding rnas cell type-specific transcriptomes cells lacking lincrna-cox2 regulate lincrna-cox2 levels genome-wide analysis tlr-induced inflammatory response lincrna-cox2 represses ccl5 activate signaling pathways previous study demonstrated studies identify lincrna-cox2 lincrna-cox2 silenced cells chromatin modifying factors ifn α/β lncrna-induced transcriptional repression hnrnpa2/b1 knockdown license information pmcid recognize microbial products 1a outer track specific binding partners chromatin signature reveals negative regulatory pathways lincrna-cox2 knockdown lncrna called nest enzymatic rna profiling interferon-γ locus interferon-gamma locus publisher site pdf
Questions {❓}
- Long intronic noncoding RNA transcription: expression noise or expression choice?
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