We are analyzing https://link.springer.com/article/10.1186/s13048-019-0588-z.

Title:
Ovarian cancer stem cells and targeted therapy | Journal of Ovarian Research
Description:
Background Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. However, tumor relapse in patients with advanced tumor stage is still a therapeutic challenge for its clinical management. Main body Therefore, it is required to clarify the molecular biology and mechanisms which are involved in chemo resistance to improve the survival rate of ovarian cancer patients. Cancer stem cells (CSCs) are a sub population of tumor cells which are related to drug resistance and tumor relapse. Conclusion In the present review, we summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients. Moreover, we focused on the targeted and combinational therapeutic methods against the ovarian CSCs.
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Keywords {🔍}

cancer, pubmed, ovarian, google, scholar, article, cells, cas, stem, cell, cscs, tumor, central, signaling, pathway, resistance, notch, therapy, method, expression, tumors, patients, role, res, carcinoma, human, treatment, wnt, oncol, targeted, clinical, epithelial, inhibitor, drug, surface, inhibition, aldh, high, breast, pathways, chemoresistance, population, methods, targeting, hedgehog, research, chemotherapy, biology, important, observed,

Topics {✒️}

seyed-reza kazemi nezhad seyed-alireza esmaeili mohammad reza abbaszadegan tgf-beta target gene wnt/β-catenin signaling contributes anti-apoptotic genes bcl-xl wnt/β –catenin-abcg2 pathway cyclophosphamide-resistant l1210 leukemia cd44-targeted hyaluronic acid-paclitaxel gene expression profile microrna-199a targets cd44 article download pdf mirna expression profiles wnt/β-catenin signaling wnt/β-catenin pathway acute b-cell leukemia bcl-2-ig fusion transcripts low-grade serous adenocarcinoma cxcr4-positive cells sorted bu‐ali research institute advanced basal-cell carcinoma ovarian cancer-initiating cells wb-dwi/mri method membrane-tethered intracellular domain cd133+ ovcar5-luc cells ƴ-secretase inhibitor ro4929097 anti-apoptotic protein bcl-2 bak pro-apoptotic proteins creb-binding protein aldh-mediated cyclophosphamide-resistance ƴ-secretase inhibitor decreased delta/serrate/lag-2 peptide cd133+/cd24+/ctr2+ cells anti-epcam× anti-cd3 atp-binding cassette pelvic serous carcinoma full access activate hedgehog signaling esa + cd44+ colon cscs γ-secretase inhibitors resulted 1a/1b phase pancreatic mir-200a decreased classic view niche-dependent tumorigenic capacity cancer stem cell cancer stem cell cd44 + cd117 + ovarian cscs stem cell niche low grade serous abcb1/mdr1/p-gp

Questions {❓}

Ovarian cancer stem cells: can targeted therapy lead to improved progression-free survival?

Schema {🗺️}

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         description:Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. However, tumor relapse in patients with advanced tumor stage is still a therapeutic challenge for its clinical management. Therefore, it is required to clarify the molecular biology and mechanisms which are involved in chemo resistance to improve the survival rate of ovarian cancer patients. Cancer stem cells (CSCs) are a sub population of tumor cells which are related to drug resistance and tumor relapse. In the present review, we summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients. Moreover, we focused on the targeted and combinational therapeutic methods against the ovarian CSCs.
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            Ovarian cancer
            Isolation
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            Drug resistance
            Gynecology
            Reproductive Medicine
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      headline:Ovarian cancer stem cells and targeted therapy
      description:Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. However, tumor relapse in patients with advanced tumor stage is still a therapeutic challenge for its clinical management. Therefore, it is required to clarify the molecular biology and mechanisms which are involved in chemo resistance to improve the survival rate of ovarian cancer patients. Cancer stem cells (CSCs) are a sub population of tumor cells which are related to drug resistance and tumor relapse. In the present review, we summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients. Moreover, we focused on the targeted and combinational therapeutic methods against the ovarian CSCs.
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         Ovarian cancer
         Isolation
         Detection
         Drug resistance
         Gynecology
         Reproductive Medicine
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      name:Immunology Research Center, Bu‐Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Immunology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran
      name:Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran
      name:Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
      name:Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
      name:Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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